通过瞬态亚硝烯和硫叶立德的高效 [4 + 1] 环加成反应温和合成异噁唑啉衍生物。
Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.
机构信息
Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China.
Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, 8 Daxue Road, Yichang, 443002, Hubei, China.
出版信息
Sci Rep. 2021 Jan 22;11(1):2078. doi: 10.1038/s41598-021-81370-w.
An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.
一种高效的[4+1]环化反应，通过在温和的碱性反应条件下原位生成亚硝烯，实现了α-溴代肟和硫叶立德之间的反应，为合成具有良好至优异收率的生物相关异噁唑啉衍生物提供了一种快速和可扩展的方法。
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