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通过瞬态亚硝烯和硫叶立德的高效 [4 + 1] 环加成反应温和合成异噁唑啉衍生物。

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

机构信息

Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China.

Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, 8 Daxue Road, Yichang, 443002, Hubei, China.

出版信息

Sci Rep. 2021 Jan 22;11(1):2078. doi: 10.1038/s41598-021-81370-w.

DOI:10.1038/s41598-021-81370-w
PMID:33483530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7822858/
Abstract

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

摘要

一种高效的[4+1]环化反应，通过在温和的碱性反应条件下原位生成亚硝烯，实现了α-溴代肟和硫叶立德之间的反应，为合成具有良好至优异收率的生物相关异噁唑啉衍生物提供了一种快速和可扩展的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/55f59f1f2906/41598_2021_81370_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/618cc39b5a88/41598_2021_81370_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/00a974216ebd/41598_2021_81370_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/03de4947cd98/41598_2021_81370_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/55f59f1f2906/41598_2021_81370_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/618cc39b5a88/41598_2021_81370_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/00a974216ebd/41598_2021_81370_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/03de4947cd98/41598_2021_81370_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a158/7822858/55f59f1f2906/41598_2021_81370_Fig4_HTML.jpg

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本文引用的文献

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J Org Chem. 2020 Mar 6;85(5):3364-3373. doi: 10.1021/acs.joc.9b03157. Epub 2020 Feb 20.
2
Retracted: Synthesis of 2-Arylisoindoline Derivatives Catalyzed by Reusable 1,2,4-Triazole Iridium on Mesoporous Silica through a Cascade Borrowing Hydrogen Strategy.撤回：通过级联借氢策略在介孔二氧化硅上由可重复使用的1,2,4-三唑铱催化合成2-芳基异吲哚啉衍生物
Chemistry. 2019 Dec 13;25(70):16099-16105. doi: 10.1002/chem.201904095. Epub 2019 Nov 19.
3
Recent Advances in Enantioselective Photochemical Reactions of Stabilized Diazo Compounds.
稳定重氮化合物的对映选择性光化学反应的最新进展。
Molecules. 2019 Sep 2;24(17):3191. doi: 10.3390/molecules24173191.
4
Visible-Light-Promoted Cascade Radical Cyclization: Synthesis of 1,4-Diketones Containing Chroman-4-One Skeletons.可见光促进的级联自由基环化反应：含色满-4-酮骨架的 1,4-二酮的合成。
Chem Asian J. 2019 Oct 1;14(19):3269-3273. doi: 10.1002/asia.201901078. Epub 2019 Sep 10.
5
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Chem Rev. 2018 Dec 12;118(23):11324-11352. doi: 10.1021/acs.chemrev.8b00375. Epub 2018 Nov 29.