National Infection Service, Public Health England, London, UK.
Rare and Imported Pathogens Laboratory, Public Health England, Porton, Salisbury, UK.
Epidemiol Infect. 2019 Sep 4;147:e262. doi: 10.1017/S0950268819001535.
The spread of the Zika virus (ZIKV) in the Americas led to large outbreaks across the region and most of the Southern hemisphere. Of greatest concern were complications following acute infection during pregnancy. At the beginning of the outbreak, the risk to unborn babies and their clinical presentation was unclear. This report describes the methods and results of the UK surveillance response to assess the risk of ZIKV to children born to returning travellers. Established surveillance systems operating within the UK - the paediatric and obstetric surveillance units for rare diseases, and national laboratory monitoring - enabled rapid assessment of this emerging public health threat. A combined total of 11 women experiencing adverse pregnancy outcomes after possible ZIKV exposure were reported by the three surveillance systems; five miscarriages, two intrauterine deaths and four children with clinical presentations potentially associated with ZIKV infection. Sixteen women were diagnosed with ZIKV during pregnancy in the UK. Amongst the offspring of these women, there was unequivocal laboratory evidence of infection in only one child. In the UK, the number and risk of congenital ZIKV infection for travellers returning from ZIKV-affected countries is very small.
寨卡病毒（ZIKV）在美洲的传播导致该地区和南半球大部分地区爆发了大规模疫情。最令人担忧的是孕妇急性感染后的并发症。在疫情爆发初期，人们对胎儿的风险及其临床表现尚不清楚。本报告描述了英国监测反应的方法和结果，以评估寨卡病毒对返回旅行者所生孩子的风险。英国现有的监测系统——儿科和产科罕见疾病监测单位以及国家实验室监测——使对这一新兴公共卫生威胁的快速评估成为可能。三个监测系统共报告了 11 名在可能感染寨卡病毒后出现不良妊娠结局的妇女；5 例流产，2 例宫内死亡和 4 例临床表现可能与寨卡病毒感染相关的儿童。在英国，共有 16 名孕妇被诊断出感染了寨卡病毒。在这些妇女的后代中，只有一个孩子的实验室证据确凿。在英国，从寨卡病毒流行国家返回的旅行者的先天性寨卡病毒感染数量和风险非常小。
