神经肽Y在神经退行性疾病和神经免疫疾病中的作用。

Li Chunrong, Wu Xiujuan, Liu Shan, Zhao Yue, Zhu Jie, Liu Kangding

Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Front Neurosci. 2019 Aug 20;13:869. doi: 10.3389/fnins.2019.00869. eCollection 2019.

Neuropeptide Y (NPY) is a neurotransmitter or neuromodulator that mainly exists in the nervous system. It plays a neuroprotective role in organisms and widely participates in the regulation of various physiological processes . Studies in both humans and animal models have been revealed that NPY levels are altered in some neurodegenerative and neuroimmune disorders. NPY plays various roles in these diseases, such as exerting a neuroprotective effect, increasing trophic support, decreasing excitotoxicity, regulating calcium homeostasis, and attenuating neuroinflammation. In this review, we will focus on the roles of NPY in the pathological mechanisms of neurodegenerative and neuroimmune diseases, highlighting NPY as a potential therapeutic target in these diseases.

神经肽Y（NPY）是一种主要存在于神经系统中的神经递质或神经调质。它在生物体中发挥神经保护作用，并广泛参与各种生理过程的调节。对人类和动物模型的研究均已表明，在某些神经退行性疾病和神经免疫性疾病中，NPY水平会发生改变。NPY在这些疾病中发挥多种作用，如发挥神经保护作用、增加营养支持、降低兴奋性毒性、调节钙稳态以及减轻神经炎症。在本综述中，我们将重点关注NPY在神经退行性疾病和神经免疫性疾病病理机制中的作用，强调NPY作为这些疾病潜在治疗靶点的重要性。