Liu Tingting, Wu Haojie, Wei Jianshe
Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, 475004, China.
Neurosci Bull. 2025 Jun 25. doi: 10.1007/s12264-025-01439-8.
Neurodegenerative diseases encompass a diverse array of disorders that have a profoundly detrimental impact on human health, characterized by their intricate and multifaceted pathogenesis. In the recent past, a growing body of scientific research has begun to shed light on the critical involvement of the neuro-immune axis in the onset and advancement of these debilitating conditions. This comprehensive review article delves into the intricate composition of the neuro-immune axis, elucidating the complex mechanisms through which it exerts its influence in the context of neurodegenerative diseases. Furthermore, it explores the potential therapeutic applications of targeting the neuro-immune axis for the management and treatment of these diseases. This extensive examination aims to offer new perspectives and innovative strategies that could pave the way for more effective treatments for neurodegenerative diseases, thereby providing hope for those afflicted by these challenging conditions.
神经退行性疾病包括一系列对人类健康有严重不利影响的疾病，其特点是发病机制复杂且多方面。近年来，越来越多的科学研究开始揭示神经免疫轴在这些使人衰弱的疾病的发生和发展中的关键作用。这篇全面的综述文章深入探讨了神经免疫轴的复杂组成，阐明了它在神经退行性疾病背景下发挥作用的复杂机制。此外，它还探讨了针对神经免疫轴进行这些疾病管理和治疗的潜在治疗应用。这项广泛的研究旨在提供新的观点和创新策略，为神经退行性疾病更有效的治疗铺平道路，从而为受这些具有挑战性疾病折磨的人带来希望。
