Yu Hui, Wang Zhanli
The Second Affiliated Hospital, Baotou Medical College, Baotou, China.
Front Physiol. 2019 Aug 20;10:1049. doi: 10.3389/fphys.2019.01049. eCollection 2019.
Exosomes, which are membrane-enclosed nanovesicles released by almost all cell types, have been recognized to play important roles in mediating cell-cell communication. In recent years, the physiological and pathological effects of exosomes on cardiovascular disease have been extensively studied. Exosomes can transfer proteins, mRNAs, microRNAs, and other bioactive molecules to recipient cells to influence their biological properties. In recent years, accumulating evidence has suggested that cardiomyocyte-derived exosomes play an important role in the progression of cardiovascular disease. Here, we summarize the functional roles of cardiomyocyte-derived exosomes in cardiovascular physiology and pathology.
外泌体是几乎所有细胞类型释放的膜包裹纳米囊泡，已被认为在介导细胞间通讯中发挥重要作用。近年来，外泌体对心血管疾病的生理和病理影响已得到广泛研究。外泌体可以将蛋白质、mRNA、微小RNA和其他生物活性分子转移到受体细胞，以影响其生物学特性。近年来，越来越多的证据表明心肌细胞衍生的外泌体在心血管疾病进展中起重要作用。在此，我们总结心肌细胞衍生外泌体在心血管生理和病理中的功能作用。
