Cui Xiaoyan, Zhang Haifang, Du Hong
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Front Microbiol. 2019 Aug 20;10:1823. doi: 10.3389/fmicb.2019.01823. eCollection 2019.
Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in the past few years, posing great challenges to human health. The plasmid-mediated horizontal transmission of carbapenem-resistance genes is the main cause of the surge in the prevalence of CRE. Therefore, the timely and accurate detection of CRE, especially carbapenemase-producing Enterobacteriaceae, is very important for the clinical prevention and treatment of these infections. A variety of methods for the rapid detection of CRE phenotypes and genotypes have been developed for use in clinical microbiology laboratories. To overcome the lack of efficient antibiotics, CRE infections are often treated with combination therapies. Moreover, novel drugs and emerging strategies appeared successively and in various stages of development. In this article, we summarized the global distribution of various carbapenemases. And we focused on summarizing and comparing the advantages and limitations of the detection methods and the therapeutic strategies of CRE primarily.
耐碳青霉烯类肠杆菌科细菌（CRE）在过去几年中已在全球迅速传播，给人类健康带来了巨大挑战。碳青霉烯耐药基因的质粒介导水平传播是CRE患病率激增的主要原因。因此，及时、准确地检测CRE，尤其是产碳青霉烯酶肠杆菌科细菌，对于这些感染的临床预防和治疗非常重要。临床微生物实验室已开发出多种用于快速检测CRE表型和基因型的方法。为克服有效抗生素的短缺，CRE感染常采用联合疗法进行治疗。此外，新型药物和新兴策略相继出现并处于不同的研发阶段。在本文中，我们总结了各种碳青霉烯酶的全球分布情况。并且我们主要着重总结和比较了CRE检测方法及治疗策略的优缺点。
