Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Office for Mental Health Support, Division for Counseling and Support, The University of Tokyo, Tokyo, Japan.
Psychiatry Clin Neurosci. 2020 Jan;74(1):40-48. doi: 10.1111/pcn.12929. Epub 2019 Oct 10.
Utena's Brief Objective Measures (UBOM) was developed to assess psychophysiological functions proximal to real-world functioning in individuals with psychiatric disorders, including schizophrenia (SCZ), to facilitate shared decision-making. However, the validity of UBOM has not been fully examined.
We conducted a cross-sectional observational study to evaluate the validity of each of the three tests in UBOM: UBOM-Pulse, UBOM-Ruler, and UBOM-Random. We investigated associations: (i) between UBOM and existing cognitive- and autonomic-function tests; and (ii) between UBOM and daily social functioning. The participants included SCZ individuals and healthy controls. We evaluated the cognitive and autonomic function using UBOM, the heart rate variability test, the simple reaction time test, and the Brief Assessment of Cognition in Schizophrenia, Japanese version. We also assessed the daily social functioning using the WHO Disability Assessment Schedule 2.0 and the modified Global Assessment of Functioning, Japanese version.
Thirty-one SCZ individuals and 35 healthy control individuals participated in this study. In the SCZ group, UBOM-Ruler was significantly associated with the Cognition and Getting Along domains of WHO Disability Assessment Schedule 2.0. UBOM-Random was significantly associated with the Brief Assessment of Cognition in Schizophrenia's Working Memory, Verbal Fluency and Attention domains, and the modified Global Assessment of Functioning in the SCZ group.
The validity of the current version of UBOM is imperfect and further improvements will be necessary to attain the originally intended goal of developing a brief assessment tool for real-world functioning in SCZ.
Utena 的简明客观测量（UBOM）旨在评估精神障碍患者（包括精神分裂症 [SCZ]）与现实世界功能相关的心理生理功能，以促进共同决策。然而，UBOM 的有效性尚未得到充分检验。
我们进行了一项横断面观察性研究，以评估 UBOM 中的三项测试的有效性：UBOM-Pulse、UBOM-Ruler 和 UBOM-Random。我们调查了以下关联：（i）UBOM 与现有的认知和自主功能测试之间的关联；以及（ii）UBOM 与日常社会功能之间的关联。参与者包括 SCZ 个体和健康对照组。我们使用 UBOM、心率变异性测试、简单反应时间测试和日本版简易认知评估来评估认知和自主功能。我们还使用世界卫生组织残疾评估量表 2.0 和日本版改良全球功能评估来评估日常社会功能。
31 名 SCZ 个体和 35 名健康对照组个体参与了这项研究。在 SCZ 组中，UBOM-Ruler 与世界卫生组织残疾评估量表 2.0 的认知和相处领域显著相关。UBOM-Random 与简易认知评估中的工作记忆、言语流畅性和注意力领域以及 SCZ 组中的改良全球功能评估显著相关。
当前版本的 UBOM 的有效性并不完善，需要进一步改进，以实现开发用于评估 SCZ 现实世界功能的简明评估工具的最初目标。
