Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Psychiatry Clinic, Etimesgut Şehit Sait Ertürk State Hospital, Ankara, Turkey.
Soc Psychiatry Psychiatr Epidemiol. 2021 Aug;56(8):1399-1410. doi: 10.1007/s00127-021-02024-w. Epub 2021 Jan 17.
It was expected that using a comprehensive scale like the Thought and Language Disorder Scale (TALD) for measurement of FTD would enable assessing its heterogeneity and its associations with cognitive impairment and functionality. This study has aimed to analyze the relationship between formal thought disorder (FTD) and cognitive functions, functionality, and quality of life in schizophrenia.
This cross-sectional exploratory study included 46 clinical participants meeting the DSM-5 diagnostic criteria for schizophrenia and 35 healthy individuals as the control groups. Data were acquired by means of the Turkish language version of the TALD, the Positive and Negative Syndrome Scale, the Clinical Global Impression Scale, the Functioning Assessment Short Test, the Social Functioning Scale, the World Health Organization Quality of Life Instrument-Short Form, and a neuropsychological test battery on executive functions, working memory, verbal fluency, abstract thinking, and response inhibition. Correlation analyses were conducted to detect significant relationships.
The clinical group scored failures in all cognitive tests. The objective positive FTD was associated with deficits in executive functions and social functioning. The objective negative FTD was associated with poor performance in all cognitive domains, physical quality of life, and social and global functioning. The subjective negative FTD was negatively correlated with psychological quality of life.
This study demonstrated that objective FTD factors reflect different underlying cognitive deficits and correlate with different functioning domains. Significant correlation was determined between subjective negative FTD and psychological quality of life. Given the close relationship of FTD with functioning and quality of life, the FTD-related cognitive deficits should be the key treatment goal in schizophrenia.
使用全面的量表，如思维和语言障碍量表（TALD）来测量 FTD，预计可以评估其异质性及其与认知障碍和功能的关联。本研究旨在分析精神分裂症中定式思维障碍（FTD）与认知功能、功能和生活质量之间的关系。
这是一项横断面探索性研究，纳入了 46 名符合 DSM-5 精神分裂症诊断标准的临床参与者和 35 名健康个体作为对照组。数据通过土耳其语版 TALD、阳性和阴性症状量表、临床总体印象量表、功能评估简短测试、社会功能量表、世界卫生组织生活质量量表-简短形式以及执行功能、工作记忆、言语流畅性、抽象思维和反应抑制的神经心理学测试组合来获取。进行了相关性分析以检测显著的关系。
临床组在所有认知测试中均出现失败。客观阳性 FTD 与执行功能和社会功能障碍相关。客观阴性 FTD 与所有认知领域、身体生活质量以及社会和总体功能的不良表现相关。主观阴性 FTD 与心理生活质量呈负相关。
本研究表明，客观 FTD 因素反映了不同的潜在认知缺陷，并与不同的功能领域相关。主观阴性 FTD 与心理生活质量之间存在显著相关性。鉴于 FTD 与功能和生活质量密切相关，FTD 相关的认知缺陷应成为精神分裂症的关键治疗目标。
