Han Min, Tang Shixing, Li Zhiju, Guan Xin, Zheng Nancai, Wang Lihua, Zhang Donghe, Hu Guifang
School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Institute of STD/AIDS Prevention and Control, Jiangmen Center for Disease Control and Prevention, Jiangmen, Guangdong, China.
AIDS Res Hum Retroviruses. 2020 Feb;36(2):134-137. doi: 10.1089/AID.2019.0141. Epub 2019 Oct 24.
New recombinant variants are a predominant challenge for preventing the spread of the HIV-1 epidemic. In this study, we confirmed a novel HIV-1 CRF07_BC/CRF55_01B recombinant form for the first time, which was isolated from a male patient in Jiangmen, China. The genomic sequence of the variant with four CRF55_01B segments inserted into the CRF07_BC backbone is 8,510 bp in length, extending from nucleotides 669 to 9,293 according to the HXB2 genome. Specifically, the recombinant strain contains site mutations associated with drug resistance.
新型重组变体是预防HIV-1疫情传播的主要挑战。在本研究中，我们首次确认了一种新型HIV-1 CRF07_BC/CRF55_01B重组形式，它是从中国江门的一名男性患者中分离出来的。该变体的基因组序列是在CRF07_BC主干中插入了四个CRF55_01B片段，长度为8510 bp，根据HXB2基因组，从核苷酸669延伸至9293。具体而言，该重组菌株含有与耐药性相关的位点突变。
Zotero 插件