HIV 感染者体内的 CD56+CD16-NK 细胞可负向调节自体 CD8+T 细胞产生 IFN-γ。
CD56 CD16 NK cells from HIV-infected individuals negatively regulate IFN-γ production by autologous CD8 T cells.
机构信息
NHC Key Laboratory of AIDS Immunology (China Medical University), Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Key Laboratory of AIDS Immunology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
J Leukoc Biol. 2019 Dec;106(6):1313-1323. doi: 10.1002/JLB.3A0819-171RR. Epub 2019 Sep 4.
The percentage of human CD56 CD16 NK cells increases during chronic infection with human HIV; however, the biologic role of CD56 CD16 NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56 CD16 NK cells producing IL-10 and TGF-β was higher than CD56 CD16 NK cells. CD56 CD16 NK cells could inhibit IFN-γ production by autologous CD8 T cells, and this inhibition could be partially reversed by anti-IL-10, anti-TGF-β, or anti-PD-L1 mAbs. CD56 CD16 NK cells are potential targets for the development of novel immune therapies against HIV infection.
在人类感染 HIV 慢性感染期间，人类 CD56 CD16 NK 细胞的比例增加；然而，CD56 CD16 NK 细胞在 HIV 感染中的生物学作用尚不清楚。我们的结果表明，产生 IL-10 和 TGF-β 的 CD56 CD16 NK 细胞的比例高于 CD56 CD16 NK 细胞。CD56 CD16 NK 细胞可抑制自体 CD8 T 细胞产生 IFN-γ，而这种抑制作用可部分被抗 IL-10、抗 TGF-β 或抗 PD-L1 mAb 逆转。CD56 CD16 NK 细胞是针对 HIV 感染开发新型免疫疗法的潜在靶点。
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