Department of Medicine, Division of Cardiology, Medical University of South Carolina, and Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
Department of Cellular and Integrative Physiology, Center for Heart and Vascular Research, University of Nebraska Medical Center, and Research Service, Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Expert Rev Proteomics. 2019 Nov-Dec;16(11-12):933-940. doi: 10.1080/14789450.2019.1664293. Epub 2019 Sep 11.
: Cardiovascular disease is a major cause of death in both men and women. While women are protected until the onset of menopause, after menopause women have increased risk of adverse cardiovascular disease events. Animal models of myocardial infarction recapitulate many of the sex differences observed in humans, and proteomics evaluations offer mechanistic insights to explain sex differences.: In this review, we will discuss how proteomics has helped us understand the hormonal, chromosomal, and immune mechanisms behind sex differences in response to ischemic injury and the development of heart failure.: There are a number of ways in which proteomics has and will continue to facilitate our understanding of sex differences in cardiac remodeling after myocardial infarction.
: 心血管疾病是男性和女性死亡的主要原因。虽然女性在绝经前受到保护，但绝经后女性患心血管疾病不良事件的风险增加。心肌梗死的动物模型再现了许多在人类中观察到的性别差异，蛋白质组学评估提供了机制上的见解，以解释对缺血性损伤和心力衰竭发展的反应中的性别差异。在这篇综述中，我们将讨论蛋白质组学如何帮助我们理解激素、染色体和免疫机制背后的性别差异，以及对缺血性损伤的反应和心力衰竭的发展。蛋白质组学有许多方法可以帮助我们理解心肌梗死后心脏重构的性别差异，并且还将继续这样做。
