Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2019 Nov;35(11):695-701. doi: 10.1002/kjm2.12125. Epub 2019 Sep 4.
Prediabetes increased risk of diabetes and diabetes-related macrovascular and microvascular complication. Glycohemoglobin (HbA ) is clinically used as the gold standard for glycemic control of diabetes. Glycated albumin (GA) is an early Amadori-type glycation protein between glucose and serum albumin, which changes in a shorter period of time than HbA and is superior to HbA in reflecting fluctuations in blood glucose. In this study, we aim to assess the predictive value of GA and glycohemoglobin (HbA1c) on a progression of diabetic retinopathy (DR) in prediabetic patients in Taiwan. This study was conducted at the outpatient department of a regional hospital in Southern Taiwan, and recruited 291 patients with prediabetes from January 2016 to February 2017. Blood and urine samples were obtained from all patients after fasting for 12 hours within 1 month of enrollment. The mean age is 62.5 ± 13.0 years and there are 161 males and 130 females. A total of 24.1% of patients have DR. The average value of GA and HbA1c are 14.6% ± 2.8% and 6.0% ± 0.4%, respectively. Old age, male, high systolic blood pressure, high HbA , and low total cholesterol are significantly associated with DR in patients with pre-DM. Therefore, in the prediabetic populations, high HbA but not GA nor GA/HbA ratio, is significantly associated with DR.
糖尿病前期增加了患糖尿病以及糖尿病大血管和微血管并发症的风险。糖化血红蛋白（HbA ）是临床上用于控制糖尿病血糖的金标准。糖化白蛋白（GA）是葡萄糖和血清白蛋白之间的早期 Amadori 型糖化蛋白，其变化时间比 HbA 短，在反映血糖波动方面优于 HbA 。在这项研究中，我们旨在评估 GA 和糖化血红蛋白（HbA1c）对台湾糖尿病前期患者糖尿病视网膜病变（DR ）进展的预测价值。这项研究在台湾南部一家地区医院的门诊部进行，招募了 291 名糖尿病前期患者，时间为 2016 年 1 月至 2017 年 2 月。所有患者在入组后 1 个月内空腹 12 小时内抽取血液和尿液样本。平均年龄为 62.5 ± 13.0 岁，男性 161 人，女性 130 人。共有 24.1%的患者有 DR 。GA 和 HbA1c 的平均数值分别为 14.6% ± 2.8%和 6.0% ± 0.4%。年龄大、男性、收缩压高、HbA 高和总胆固醇低与 DM 前期患者的 DR 显著相关。因此，在糖尿病前期人群中，高 HbA 而非 GA 或 GA/HbA 比值与 DR 显著相关。
