动物源产超广谱β-内酰胺酶细菌的流行情况：来自印度的系统评价和荟萃分析报告。
Prevalence of extended-spectrum beta-lactamase producing bacteria from animal origin: A systematic review and meta-analysis report from India.
机构信息
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, India.
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States of America.
出版信息
PLoS One. 2019 Sep 4;14(9):e0221771. doi: 10.1371/journal.pone.0221771. eCollection 2019.
Antimicrobial resistance (AMR) due to the emergence and spread of extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming a serious global public health concern. This article aims to assess the overall prevalence of ESBLs among animals in India, with year-wise, zone-wise and species-wise stratification. Systematic search from PubMed, Google Scholar and J-Gate Plus was carried out and 24 eligible articles from 2013-2019 in India were retrieved. The R Open source Scripting software was used to perform statistical analysis. The overall prevalence of ESBLs among animals in India was 9%. The pooled prevalence of ESBLs in animals were 26, 11, 6 and 8% for north, east, south and central zones, respectively. The reported prevalence of ESBLs in animals were 12, 5, 8, 8, 12, 13 and 33% were reported for the years 2013, 2014, 2015, 2016, 2017, 2018, 2019 respectively. The species-wise stratified results showed a predominance of ESBL producing Klebsiella pneumoniae strains (11%) when compared to Escherichia coli and Pseudomonas spp. which were 7% and 5%, respectively. The prevalence data generated could be utilized in infection control and in antibiotic use management decisions for developing appropriate intervention strategies.
由于广谱β-内酰胺酶（ESBL）产生细菌的出现和传播，导致抗菌药物耐药性（AMR）成为一个严重的全球公共卫生问题。本文旨在评估印度动物中 ESBL 的总体流行率，并进行逐年、分区和物种分层分析。通过对 PubMed、Google Scholar 和 J-Gate Plus 进行系统检索，共检索到 2013 年至 2019 年印度的 24 篇合格文章。使用 R 开源脚本软件进行统计分析。印度动物中 ESBL 的总体流行率为 9%。北方、东方、南方和中央区的动物中 ESBL 的总流行率分别为 26%、11%、6%和 8%。2013 年、2014 年、2015 年、2016 年、2017 年、2018 年和 2019 年，报告的动物中 ESBL 流行率分别为 12%、5%、8%、8%、12%、13%和 33%。与大肠杆菌和铜绿假单胞菌（分别为 7%和 5%）相比，产 ESBL 的肺炎克雷伯菌菌株（11%）更为常见。生成的流行率数据可用于感染控制和抗生素使用管理决策，以制定适当的干预策略。
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