分子钟在促进骨骼肌生长和预防肌肉减少症中的作用。
The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia.
机构信息
IRCCS Istituto Ortopedico Galeazzi, LaMSS-Laboratory of Movement and Sport Science, Via Giuseppe Galeazzi 4, 20161 Milano, Italy.
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Giuseppe Colombo 71, 20133 Milano, Italy.
出版信息
Int J Mol Sci. 2019 Sep 3;20(17):4318. doi: 10.3390/ijms20174318.
Abstract
The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia. Therefore, the aim of this review is to present the latest findings demonstrating how circadian rhythms in skeletal muscle are important for maintenance of the cellular physiology, metabolism and function of skeletal muscle. Moreover, we will present the current knowledge about the tissue-specific functions of the molecular clock in skeletal muscle.
摘要
生物钟在骨骼肌的许多生理功能中起着关键作用，对于充分了解这些复杂相互作用所涉及的精确潜在机制至关重要。当观察到生物钟破坏模型中的肌肉表型时，生物钟对骨骼肌结构、功能和代谢的表达的重要性就显而易见了。目前，生物钟的维持作为人类健康的一个重要新因素正在出现，其紊乱与衰老以及许多慢性疾病的发展有关，包括肌肉减少症。因此，本综述的目的是介绍最新的研究结果，这些结果表明骨骼肌中的生物钟节律如何对维持骨骼肌的细胞生理学、代谢和功能很重要。此外，我们将介绍目前关于分子钟在骨骼肌中的组织特异性功能的知识。
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