Yi Whitley M, Van Wieren Jones Emily M, Hansen B Kyle, Vora Jay
P T. 2019 Sep;44(9):554-559.
Self-monitoring of bood glucose alone is not a good predictor of HbA goal attainment. Health plans might benefit from formulary restrictions to provide more cost-effective care, without negatively impacting glycemic control. And by using targeted inteventions, healthcare providers could help maximize SMBG's clinical benefit for patients who receive test strips. Self-monitoring of blood glucose (SMBG) can be an important tool in diabetes treatment, both for patient self-management and for guiding clinicians regarding medication adjustments. Evidence supports the association of SMBG with clinical outcomes in patients with type-1 diabetes mellitus (T1DM) although it is mixed for patients with type-2 diabetes mellitus (T2DM). The cost of SMBG comprises a substantial portion of the total cost for patients with diabetes, and test strips are one of the main expenditures of the University of North Carolina Medical Center Pharmacy Assistance Program (PAP), which provides medication coverage, including test strips, to indigent patients who have no pharmacy insurance. The objective of this study is to evaluate the utility of SMBG based on the impact of test-strip adherence on glycemic goal attainment in an indigent population that is provided with low-copay test strips. This retrospective cohort study included patients with T1DM or T2DM who were enrolled in PAP in 2016 and who received a prescription for test strips during the 90 days prior to hemoglobin A1c (HbA) measurement. Adherence was defined as the proportion of days covered (PDC) > 0.8. Of the 498 patients encountered, 20% of the adherent group (n = 245) and 25% of the nonadherent group (n = 253) had a goal of HbA < 7% ( = 0.24). There were no differences in mean HbA between the groups, except in the multiple daily injections (MDI) of the insulin subgroup (8.9% vs. 9.6%, = 0.009). The adherent group was 80% less likely to have a diabetes-related hospitalization (odds ratio [OR], 0.2; 95% CI, 0.04-0.92). The total test-strip cost to PAP was more than $200,000. In conclusion, in an indigent population, adherence to SMBG does not correlate with glycemic goal attainment and imposes a substantial cost burden on the healthcare system.
仅进行血糖自我监测并不能很好地预测糖化血红蛋白(HbA)目标的达成情况。医保计划可能会受益于药品目录限制,从而提供更具成本效益的医疗服务,同时又不会对血糖控制产生负面影响。通过采用有针对性的干预措施,医疗服务提供者可以帮助接受试纸检测的患者最大限度地提高自我血糖监测(SMBG)的临床效益。血糖自我监测(SMBG)在糖尿病治疗中可以是一项重要工具,既有助于患者自我管理,也有助于指导临床医生调整用药。有证据支持SMBG与1型糖尿病(T1DM)患者的临床结局相关,尽管在2型糖尿病(T2DM)患者中情况不一。SMBG的费用在糖尿病患者的总费用中占很大一部分,试纸是北卡罗来纳大学医学中心药房援助计划(PAP)的主要支出项目之一,该计划为没有药房保险的贫困患者提供包括试纸在内的药物保险。本研究的目的是基于试纸依从性对血糖目标达成情况的影响,评估贫困人群中SMBG的效用,这些贫困人群获得了低自付费用的试纸。这项回顾性队列研究纳入了2016年参加PAP且在糖化血红蛋白(HbA)测量前90天内接受试纸处方的T1DM或T2DM患者。依从性定义为覆盖天数比例(PDC)>0.8。在遇到的498名患者中,依从组(n = 245)的20%和非依从组(n = 253)的25%的目标是HbA<7%(P = 0.24)。除胰岛素亚组的多次每日注射(MDI)情况外(8.9%对9.6%,P = 0.009),两组之间的平均HbA没有差异。依从组发生糖尿病相关住院的可能性低80%(比值比[OR],0.2;95%置信区间,0.04 - 0.92)。PAP的试纸总费用超过20万美元。总之,在贫困人群中,SMBG的依从性与血糖目标达成情况无关,且给医疗系统带来了巨大的成本负担。