Hashim Fauzy Fatimatuzzahra, Mohd Zainudin Maizura, Ismawi Hidayatul Radziah, Elshami Taher F T
Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia.
Evid Based Complement Alternat Med. 2019 Aug 14;2019:7198592. doi: 10.1155/2019/7198592. eCollection 2019.
is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb's antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures ( < 0.05) of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level ( < 0.05) and reduced endothelin-1 (ET-1) level ( < 0.05) in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.
是一种东南亚的热带植物，以其在治疗包括高血压在内的各种疾病方面的传统用途而闻名。先前的研究工作已经为这种草药的降压特性提供了证据。然而，其中的确切机制仍存在疑问。本研究调查了叶水提取物（PSAE）处理对自发性高血压大鼠（SHRs）血管内皮素系统的影响。四组SHRs连续治疗28天，阴性和阳性对照组分别接受蒸馏水和3 mg/kg培哚普利。另外两组为治疗组，分别接受PSAE以及1.5 mg/kg培哚普利与PSAE的组合。每周测量血压显示，PSAE显著降低了大鼠的收缩压、舒张压和平均动脉压（P<0.05）。在治疗组中，PSAE还提高了肠系膜动脉一氧化氮（NO）水平（P<0.05）并降低了内皮素-1（ET-1）水平（P<0.05）。我们的结果表明，口服PSAE通过降低ET-1水平同时增加NO生成来降低SHRs的血压。
