Shin Yong Un, Kim Ji Hong, Cho Heeyoon, Kim Dae Sung, Yi Joo-Hark, Han Sang-Woong, Seong Mincheol
Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Division of Nephrology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
J Ophthalmol. 2019 Aug 14;2019:2406547. doi: 10.1155/2019/2406547. eCollection 2019.
To investigate the effect of hemodialysis (HD) on the anterior chamber angle by anterior segment optical coherence tomography (ASOCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD).
A prospective observational study was performed on 20 patients who underwent HD for ESKD. Anterior chamber angle images were obtained by 16 mm line scan of ASOCT. The angle opening distance (AOD) and the trabecular-iris space area (TISA) were determined using the ImageJ program. Additional 12 mm horizontal and 9 mm vertical wide-field scans centered on the posterior pole were performed for the measurement of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness. Changes in intraocular pressure (IOP), AOD, TISA, pRNFL thickness, and mGCIPL thickness before and after HD were statistically analyzed.
The IOP decreased significantly from 17.5 ± 3.4 before HD to 16.2 ± 2.3 after HD (=0.017). There was a statistically significant decrease in AOD 750 and TISA 750 (=0.005 and =0.007, respectively). AOD 500 and TISA 500 also decreased, which was almost statistically significant (=0.061 and =0.081, respectively). Mean pRNFL thickness and mGCIPL thickness did not show significant change after HD.
We observed a significant decrease in IOP and anterior chamber angle measurements after HD. Our study suggests that HD can influence the anterior segment structure of eyes.
通过眼前节光学相干断层扫描（ASOCT）及其他眼科参数，研究血液透析（HD）对终末期肾病（ESKD）患者前房角的影响。
对20例接受HD治疗的ESKD患者进行前瞻性观察研究。通过ASOCT的16毫米线扫描获取前房角图像。使用ImageJ程序确定房角开放距离（AOD）和小梁-虹膜间隙面积（TISA）。以视盘后极部为中心进行额外的12毫米水平和9毫米垂直宽视野扫描，测量视网膜神经纤维层（pRNFL）厚度和黄斑神经节细胞-内丛状层（mGCIPL）厚度。对HD前后的眼压（IOP）、AOD、TISA、pRNFL厚度和mGCIPL厚度变化进行统计学分析。
HD后IOP从HD前的17.5±3.4显著降至16.2±2.3（P=0.017）。AOD 750和TISA 750有统计学显著降低（分别为P=0.005和P=0.007）。AOD 500和TISA 500也有所降低，几乎具有统计学意义（分别为P=0.061和P=0.081）。HD后平均pRNFL厚度和mGCIPL厚度未显示出显著变化。
我们观察到HD后IOP和前房角测量值显著降低。我们的研究表明HD可影响眼部前段结构。
