Maram Jyotsna, Pan Xiaojing, Sadda Srinivas, Francis Brian, Marion Kenneth, Chopra Vikas
Doheny Image Reading Center, Doheny Eye Institute , Los Angeles, CA , USA .
Curr Eye Res. 2015 May;40(5):496-500. doi: 10.3109/02713683.2014.930155. Epub 2014 Jun 23.
To evaluate the reproducibility of anterior chamber angle measurements obtained by the Zeiss Visante anterior segment optical coherence tomography (AS-OCT).
Twenty eyes from 20 normal subjects with open anterior chamber angles were studied. The anterior chamber angle was imaged using the Visante AS-OCT. The angle-opening distance (AOD 500, AOD 750), trabercular iris space area (TISA 500, TISA 750) and scleral spur angle (SS angle) at the inferior angle location were measured. All the subjects underwent imaging in a darkened room (1 foot candles measured at the eye). Images were graded in a masked fashion by certified Doheny Image Reading Center graders. For intra-grader reproducibility assessments, images were re-graded by the same grader 1 week later after random sorting of images. For inter-grader assessments, a second masked grader independently reviewed the images. Intraclass correlation coefficients (ICC) were used to assess reproducibility.
Inferior angle measurements of AOD (500, 750), TISA (500, 750) and SS angle for 20 normal eyes were calculated. The intra-observer ICC calculations showed excellent reproducibility for all measurements (AOD 500 = 0.95, AOD 750 = 0.97, TISA 500 = 0.93, TISA 750 = 0.94, SS = 0.96; p < 0.001 for all). The inter-observer ICC calculations showed lower reproducibility for all measurements (AOD 500 = 0.71, p < 0.001; AOD 750 = 0.82, p < 0.001; TISA 500 = 0.49, p = 0.08; TISA 750 = 0.61, p = 0.02; SS = 0.75).
Determination of anterior chamber angle measurements was possible with the time-domain AS-OCT, but only modest inter-observer reproducibility was found even among experienced graders.
评估使用蔡司Visante眼前节光学相干断层扫描（AS-OCT）获得的前房角测量值的可重复性。
对20名前房角开放的正常受试者的20只眼睛进行研究。使用Visante AS-OCT对前房角进行成像。测量下角位置的房角开放距离（AOD 500、AOD 750）、小梁虹膜间隙面积（TISA 500、TISA 750）和巩膜突角（SS角）。所有受试者均在暗室（眼睛处测量为1英尺烛光）中进行成像。图像由认证的多希尼图像阅读中心评分员以盲法进行评分。对于评分员内部可重复性评估，在对图像进行随机排序后1周，由同一名评分员对图像重新评分。对于评分员间评估，第二名盲法评分员独立审查图像。使用组内相关系数（ICC）评估可重复性。
计算了20只正常眼睛的下角AOD（500、750）、TISA（500、750）和SS角的测量值。观察者内ICC计算显示所有测量值均具有出色的可重复性（AOD 500 = 0.95，AOD 750 = 0.97，TISA 500 = 0.93，TISA 750 = 0.94，SS = 0.96；所有p < 0.001）。观察者间ICC计算显示所有测量值的可重复性较低（AOD 500 = 0.71，p < 0.001；AOD 750 = 0.82，p < 0.001；TISA 500 = 0.49，p = 0.08；TISA 750 = 0.61，p = 0.02；SS = 0.75）。
使用时域AS-OCT可以确定前房角测量值，但即使在经验丰富的评分员中，观察者间的可重复性也仅为中等。
