Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA.
Mol Imaging Biol. 2020 Jun;22(3):463-475. doi: 10.1007/s11307-019-01414-6.
The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to date. Finally, we discuss the prospects for the future of this field, including the potential of newly envisioned devices developed that may allow operators to easily synthesize specialized tracers for individual patient doses.
目前，正电子发射断层扫描（PET）成像的应用受到限制，这是由于生产设施启动和运营成本高所致；因此，人们开始转向微流控合成放射性标记的成像药物（示踪剂）。在这篇综述中，我们总结了用于生产氟-18 标记的 PET 成像示踪剂的微流控放射合成装置的现状，包括讨论这些装置的相对优缺点。此外，我们还简要概述了迄今为止使用微流控设备生产的放射性示踪剂。最后，我们讨论了该领域的未来前景，包括新设想的设备可能为操作员提供的潜力，这些设备可以方便地为个别患者剂量合成专门的示踪剂。
