National Centre of Excellence in Analytical Chemistry (NCEAC), University of Sindh, Jamshoro, 76080, Pakistan.
Department of Dermatology, Liaquat University of Medical and Health Sciences, Jamshoro, 76080, Pakistan.
Environ Sci Pollut Res Int. 2019 Nov;26(31):31763-31769. doi: 10.1007/s11356-019-06226-3. Epub 2019 Sep 4.
Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system and environmental factors. In the present study, cadmium (Cd) and zinc (Zn) were analyzed in biological samples (blood and scalp hair) of smoker and nonsmoker males who have mild and severe psoriasis. The patients were evaluated according to criteria based on the standard clinical diagnosis and classified into mild and severe psoriasis groups using the Psoriasis Area Severity Index (PASI) score. Both elements were determined by atomic absorption spectrometry after matrix oxidation. In smoker psoriatic patients, the level of Cd in biological samples was significantly increased. The Zn was significantly decreased in smoker mild and severe psoriatic patients as related to nonsmokers' referents and patients. The resulted data indicated that the levels of Zn in smoker referents were about 5.0% lower than nonsmoker's referents. While the concentrations of Zn in blood samples of nonsmoker's mild and severe psoriatic patients have 17.8 to 33.3% lower than nonsmoker's referents. The results indicate that the level of Cd in blood samples of referent smokers has ≥ 25% than nonsmokers, whereas the psoriatic patients at different stages have two- to threefold higher Cd in both biological samples.
银屑病是一种皮肤炎症性疾病，源于免疫系统和环境因素的失调相互作用。在本研究中，分析了轻度和重度银屑病男性吸烟者和非吸烟者的生物样本（血液和头皮毛发）中的镉（Cd）和锌（Zn）。根据基于标准临床诊断的标准，对患者进行评估，并使用银屑病面积严重程度指数（PASI）评分将患者分为轻度和重度银屑病组。在基质氧化后，通过原子吸收光谱法测定这两种元素。在吸烟的银屑病患者中，生物样本中的 Cd 水平明显升高。与非吸烟者参考值和患者相比，吸烟的轻度和重度银屑病患者的 Zn 明显降低。结果表明，吸烟参考者的 Zn 水平比非吸烟参考者低约 5.0%。而在非吸烟的轻度和重度银屑病患者的血液样本中，Zn 的浓度比非吸烟参考者低 17.8%至 33.3%。结果表明，参考吸烟者血液样本中的 Cd 水平比非吸烟者高≥25%，而不同阶段的银屑病患者在两种生物样本中 Cd 水平均高出两到三倍。
