Department of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan.
J Am Geriatr Soc. 2019 Nov;67(11):2362-2369. doi: 10.1111/jgs.16109. Epub 2019 Sep 4.
To examine the association between hearing aids (HAs) and time to diagnosis of Alzheimer disease (AD) or dementia, anxiety or depression, and injurious falls among adults, aged 66 years and older, within 3 years of hearing loss (HL) diagnosis.
Retrospective cohort study.
We used 2008 to 2016 national longitudinal claims data (based on office visit, inpatient, or outpatient healthcare encounters) from a large private payer. We used Kaplan-Meier curves to examine unadjusted disease-free survival and crude and adjusted Cox regression models to examine associations between HAs and time to diagnosis of three age-related/HL-associated conditions within 3 years of HL diagnosis. All models were adjusted for age, sex, race/ethnicity, census divisions, and prior diagnosis of cardiovascular conditions, hypertension, hypercholesterolemia, obesity, and diabetes.
The participants included 114 862 adults, aged 66 years and older, diagnosed with HL.
Diagnosis of (1) AD or dementia; (2) depression or anxiety; and (3) injurious falls.
Use of HAs.
Large sex and racial/ethnic differences exist in HA use. Approximately 11.3% of women vs 13.3% of men used HAs (95% confidence interval [CI] difference = -0.024 to -0.016). Approximately 13.6% of whites (95% CI = 0.13-0.14) vs 9.8% of blacks (95% CI = 0.09-0.11) and 6.5% of Hispanics (95% CI = 0.06-0.07) used HAs. The risk-adjusted hazard ratios of being diagnosed with AD/dementia, anxiety/depression, and injurious falls within 3 years after HL diagnosis, for those who used HAs vs those who did not, were 0.82 (95% CI = 0.76-0.89), 0.89 (95% CI = 0.86-0.93), and 0.87 (95% CI = 0.80-0.95), respectively.
Use of HAs is associated with delayed diagnosis of AD, dementia, depression, anxiety, and injurious falls among older adults with HL. Although we have shown an association between use of HAs and reduced risk of physical and mental decline, randomized trials are needed to determine whether, and to what extent, the relationship is causal. J Am Geriatr Soc 67:2362-2369, 2019.
在听力损失(HL)诊断后 3 年内,检查助听器(HA)与阿尔茨海默病(AD)或痴呆、焦虑或抑郁、伤害性跌倒的诊断时间之间的关联,研究对象为年龄在 66 岁及以上的成年人。
回顾性队列研究。
我们使用了来自一家大型私人支付者的 2008 年至 2016 年全国纵向索赔数据(基于门诊、住院或门诊医疗保健就诊)。我们使用 Kaplan-Meier 曲线来检查无疾病生存的未经调整情况,以及使用未调整和调整后的 Cox 回归模型来检查 HA 与 HL 诊断后 3 年内与三种年龄相关/HL 相关疾病的诊断时间之间的关联。所有模型均根据年龄、性别、种族/民族、人口普查区以及心血管疾病、高血压、高胆固醇血症、肥胖症和糖尿病的先前诊断进行了调整。
共有 114862 名年龄在 66 岁及以上、被诊断为 HL 的成年人参与了该研究。
(1)AD 或痴呆的诊断;(2)抑郁或焦虑的诊断;以及(3)伤害性跌倒的诊断。
HA 的使用。
HA 的使用存在较大的性别和种族/民族差异。大约 11.3%的女性和 13.3%的男性使用了 HA(95%置信区间[CI]差值=-0.024 至-0.016)。大约 13.6%的白人(95%CI=0.13-0.14)和 9.8%的黑人(95%CI=0.09-0.11)以及 6.5%的西班牙裔(95%CI=0.06-0.07)使用了 HA。与未使用 HA 的人相比,在 HL 诊断后 3 年内被诊断为 AD/痴呆、焦虑/抑郁和伤害性跌倒的风险调整后的危险比(HR)分别为 0.82(95%CI=0.76-0.89)、0.89(95%CI=0.86-0.93)和 0.87(95%CI=0.80-0.95)。
在 HL 老年患者中,使用 HA 与 AD、痴呆、抑郁、焦虑和伤害性跌倒的诊断时间延迟有关。尽管我们已经证明了使用 HA 与身体和精神衰退风险降低之间存在关联,但需要进行随机试验来确定这种关系是否以及在何种程度上具有因果关系。美国老年医学会 67:2362-2369,2019。