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提取物改善城市颗粒物引起的干眼症。

Extract Improves Urban Particulate Matter-Induced Dry Eye Disease.

机构信息

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

出版信息

Int J Environ Res Public Health. 2019 Sep 4;16(18):3229. doi: 10.3390/ijerph16183229.

DOI:10.3390/ijerph16183229
PMID:31487776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6765805/
Abstract

Dry eye disease (DED) is a multifactorial inflammatory disease that severely impairs patients' quality of life. Particulate matter comprises a harmful mixture of particles less than 10 μm in size, which on contact with the eye, causes inflammation in the cornea/conjunctival epithelium, threatening eye health and triggering the onset of DED. is an ingredient of traditional medicine generally used for treating osteoporosis, trauma, and thrombosis in Asian countries. However, the effect of on eye health has not been elucidated. In this study, we evaluate the protective effect of hot water extract (ARE) in a rat model of urban particulate matter (UPM)-induced DED. UPM with or without ARE were topically administered on both eyes thrice daily for 10 days. ARE induced tear secretion and improved corneal irregularity. Additionally, ARE treatment protected the corneal epithelial cells from UPM-induced apoptosis. It also restored rMuc4 expression in the cornea and increased goblet cell density in the conjunctiva. These results are suggestive of the potential of ARE as a topical therapeutic agent for treating DED.

摘要

干眼症（DED）是一种多因素炎症性疾病，严重影响患者的生活质量。颗粒物由小于 10μm 的颗粒有害物质组成，与眼睛接触后会引起角膜/结膜上皮炎症，威胁眼睛健康并引发 DED。 是亚洲传统医学中的一种成分，通常用于治疗骨质疏松症、创伤和血栓形成。然而， 对眼睛健康的影响尚未阐明。在这项研究中，我们评估了 热水提取物（ARE）在大鼠城市颗粒物（UPM）诱导的 DED 模型中的保护作用。将 UPM 或 ARE 局部涂抹于双眼，每天三次，持续 10 天。ARE 诱导泪液分泌并改善角膜不规则性。此外，ARE 治疗可保护角膜上皮细胞免受 UPM 诱导的凋亡。它还恢复了角膜中的 rMuc4 表达并增加了结膜中的杯状细胞密度。这些结果表明 ARE 有作为治疗 DED 的局部治疗剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/9e3ce7212d91/ijerph-16-03229-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/b710216184c5/ijerph-16-03229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/ad6020d45c77/ijerph-16-03229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/e4a88704eb9d/ijerph-16-03229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/60cb4f55eb66/ijerph-16-03229-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/1aa0733efed5/ijerph-16-03229-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/9e3ce7212d91/ijerph-16-03229-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/b710216184c5/ijerph-16-03229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/ad6020d45c77/ijerph-16-03229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/e4a88704eb9d/ijerph-16-03229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/60cb4f55eb66/ijerph-16-03229-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/1aa0733efed5/ijerph-16-03229-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f74/6765805/9e3ce7212d91/ijerph-16-03229-g006.jpg

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