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用于干眼症治疗的提取物负载型滴眼液制剂研发及新型评价方法

Extract-Loaded Eye Drop Formulation Development and Novel Evaluation Method for Dry Eye Treatment.

作者信息

Kim Sung-Jin, Park Bongkyun, Huh Hyun Wook, Na Young-Guk, Kim Minki, Han Mingu, Lee Hyunmin, Pham Thi Mai Anh, Lee Hong-Ki, Lee Jae-Young, Kim Chan-Sik, Baek Jong-Suep, Cho Cheong-Weon

机构信息

College of Pharmacy and Institute of Drug Research & Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

出版信息

Pharmaceutics. 2020 Feb 17;12(2):165. doi: 10.3390/pharmaceutics12020165.

DOI:10.3390/pharmaceutics12020165
PMID:32079194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7076473/
Abstract

Recently, extract has been studied as a therapeutic agent for dry eye disease that occurs from fine dust. The aim of this study was the development of extract-loaded eye drop formulations using lubricants, generally used for artificial tear eye drops. Ecdysterone was used as a marker compound for extract and 1% extract solution contained 14.37 ± 0.04 μg/mL of ecdysterone. Before formulation studies, a new method was performed to evaluate pigmentation, which might be caused by eye drops of herbal extract. A comparative study of the water retention ability of each formulation and ability to prevent the death of conjunctival epithelial cells in dry conditions was conducted. Moreover, treatment of extract (USL) eye drop formulation exhibited a significant inhibitory effect on inflammation in a concentration-dependent manner. The long-term and accelerated stability tests showed that lubricants could contribute to the stability of herbal extracts in solution. In conclusion, hyaluronic acid showed a good effect on the development of eye drop formulation using extracts for treating dry eye disease.

摘要

最近，提取物已被作为一种治疗因细粉尘导致的干眼症的治疗剂进行研究。本研究的目的是开发使用通常用于人工泪液滴眼液的润滑剂的含提取物的滴眼剂配方。蜕皮甾酮用作提取物的标记化合物，1%的提取物溶液含有14.37±0.04μg/mL的蜕皮甾酮。在配方研究之前，采用了一种新方法来评估可能由草药提取物滴眼液引起的色素沉着。对每种配方的保水能力以及在干燥条件下防止结膜上皮细胞死亡的能力进行了比较研究。此外，提取物（USL）滴眼剂配方的处理以浓度依赖性方式对炎症表现出显著的抑制作用。长期和加速稳定性试验表明，润滑剂有助于草药提取物在溶液中的稳定性。总之，透明质酸对使用提取物治疗干眼症的滴眼剂配方的开发显示出良好效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/396e73452238/pharmaceutics-12-00165-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/90eb06a47034/pharmaceutics-12-00165-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/82e1eb98bbc8/pharmaceutics-12-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/fdb674c7d057/pharmaceutics-12-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/341c27c81804/pharmaceutics-12-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/9e045f614c3d/pharmaceutics-12-00165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/396e73452238/pharmaceutics-12-00165-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/90eb06a47034/pharmaceutics-12-00165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/0f3bf29f29d2/pharmaceutics-12-00165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/82e1eb98bbc8/pharmaceutics-12-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/fdb674c7d057/pharmaceutics-12-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/341c27c81804/pharmaceutics-12-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/9e045f614c3d/pharmaceutics-12-00165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0d5/7076473/396e73452238/pharmaceutics-12-00165-g007.jpg

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