Cicciù Marco, Cervino Gabriele, Fiorillo Luca, D'Amico Cesare, Oteri Giacomo, Troiano Giuseppe, Zhurakivska Khrystyna, Lo Muzio Lorenzo, Herford Alan Scott, Crimi Salvatore, Bianchi Alberto, Di Stasio Dario, Rullo Rosario, Laino Gregorio, Laino Luigi
Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, 98100 Messina, Italy.
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, 34109 Naples, Italy.
Dent J (Basel). 2019 Sep 4;7(3):93. doi: 10.3390/dj7030093.
The fluorescence method is an innovative technique used by pathologists for examining body mucosa, and for the abnormalities tissue screening, potentially leading to the earlier discovery of pre-cancer, cancer or other disease processes. The early detection is one of the best mechanisms for enabling treatment success, increasing survival rates and maintaining a high quality of life. The purpose of this review is to evaluate the clinical efficiency of this diagnostic tool applied to the oral cavity (VELscope). A literature systematic review has been performed. The initial research provided 53 results after applying the inclusion and exclusion criteria, and after a manual screening of the abstracts by the authors, only 25 results were eligible for review. The results and data contained in all the researches, no older than 10 years, were manually evaluated, and provided useful information on this diagnostic method. The VELscope mean value about sensitivity and specificity resulted of 70.19% and 65.95%, respectively, by results analysis, but despite this some studies disagree about its clinical effectiveness, and this diagnostic method is still much debated in scientific and clinical medical literature. Surely being able to have efficient and effective tools from this point of view could help the clinician in the diagnosis, and also make timelier the pharmacological or surgical therapy, improving the quality of life of the patient, and in some cases guaranteeing a longer survival term.
荧光法是病理学家用于检查身体黏膜以及筛查异常组织的一种创新技术，有可能更早地发现癌前病变、癌症或其他疾病进程。早期检测是实现治疗成功、提高生存率和维持高质量生活的最佳机制之一。本综述的目的是评估这种应用于口腔的诊断工具（VELscope）的临床效率。已进行了文献系统综述。在应用纳入和排除标准后，初步研究得到了53个结果，经过作者对摘要的人工筛选，仅有25个结果符合综述要求。对所有不超过10年的研究中包含的结果和数据进行了人工评估，得到了关于这种诊断方法的有用信息。通过结果分析，VELscope的敏感性和特异性平均值分别为70.19%和65.95%，但尽管如此，一些研究对其临床有效性存在不同意见，并且这种诊断方法在科学和临床医学文献中仍备受争议。从这一角度来看，拥有高效且有效的工具肯定有助于临床医生进行诊断，还能使药物或手术治疗更加及时，提高患者的生活质量，在某些情况下还能保证更长的生存期。
