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[利布曼-萨克斯心内膜炎合并感染:病例报告]

[Libman-Sacks endocarditis superinfected: a case report].

作者信息

Ramiandrisoa Lahatriniavo Ritchy, Raveloson Haingo Freddie Richard, Rakotoniaina Daniella Masinarivo, Rabearivony Nirina, Rakotoarimanana Solofonirina

机构信息

Faculté de Médecine, Université d'Antananarivo, Service des Soins Intensifs Cardiologiques, CHU Befelatanana, Antananarivo, Madagascar.

Faculté de Médecine, Université d'Antananarivo, Service de Cardiologie, CHU Befelatanana, Antananarivo, Madagascar.

出版信息

Pan Afr Med J. 2019 Jun 10;33:97. doi: 10.11604/pamj.2019.33.97.9597. eCollection 2019.

Abstract

Libman-Sacks endocarditis is a rare cardiac manifestation systemic lupus erythematosus, in which there is a sterile vegetation in the heart valves. There is a significant risk of infective endocarditis. Our patient was a 38 year old woman with persistent fever from two months with inflammatory polyarthralgia, fixed at the wrists and ankles. She was febrile at 39 ° C, had a mitral systolic murmur 2/6 and painful swelling of the wrists and ankles. We have objectified an inflammatory syndrome, blood cultures were negative. The dosage of anti-nuclear antibody was positive with a mottled appearance, as well as anti-DNA antibodies. The Doppler echocardiography had objectified vegetations in the mitral and aortic valves. Clinical, biological and morphological improvements were obtained after antibiotic and corticosteroid combination. We can conclude that Libman-Sacks endocarditis evolution is favorable in the absence of an associated antiphospholipid syndrome (APS). Always fear in all cases a surinfection. The treatment is based on the combination antibiotic-corticosteroid-synthetic antimalarial.

摘要

利布曼-萨克斯心内膜炎是系统性红斑狼疮一种罕见的心脏表现,其中心脏瓣膜会出现无菌性赘生物。存在感染性心内膜炎的重大风险。我们的患者是一名38岁女性,持续发热两个月,伴有炎症性多关节痛,固定于手腕和脚踝。她体温达39℃,有二尖瓣收缩期杂音2/6级,手腕和脚踝疼痛肿胀。我们发现了一种炎症综合征,血培养阴性。抗核抗体检测呈阳性,呈斑点状外观,抗DNA抗体也是如此。多普勒超声心动图发现二尖瓣和主动脉瓣有赘生物。抗生素和皮质类固醇联合使用后,临床、生物学和形态学均有改善。我们可以得出结论,在无相关抗磷脂综合征(APS)的情况下,利布曼-萨克斯心内膜炎的病情发展是有利的。在所有情况下都要始终警惕继发感染。治疗基于抗生素-皮质类固醇-合成抗疟药联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c31/6711674/7e1bfe8a2381/PAMJ-33-97-g001.jpg

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