Lee Jennifer L, Naguwa Stanley M, Cheema Gurtej S, Gershwin M Eric
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA.
Clin Rev Allergy Immunol. 2009 Jun;36(2-3):126-30. doi: 10.1007/s12016-008-8113-y.
Libman-Sacks (LS) endocarditis was first described by Libman and Sacks in 1924, and is characterized by sterile, verrucous valvular lesions with a predisposition for the mitral and aortic valves. It is now regarded as both a cardiac manifestation of systemic lupus erythematosus and, in recent years, of the antiphospholipid syndrome (APS). Though typically mild and asymptomatic, LS endocarditis can lead to significant complications, including severe valvular insufficiency requiring surgery, infective endocarditis, and thromboembolic events, such as stroke and transient ischemic events. Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS.
利布曼-萨克斯（Libman-Sacks，LS）心内膜炎于1924年由利布曼和萨克斯首次描述，其特征为无菌性疣状瓣膜病变，好发于二尖瓣和主动脉瓣。如今，它被视为系统性红斑狼疮以及近年来抗磷脂综合征（APS）的心脏表现。尽管LS心内膜炎通常症状轻微且无症状，但可导致严重并发症，包括需要手术治疗的严重瓣膜关闭不全、感染性心内膜炎以及血栓栓塞事件，如中风和短暂性缺血事件。成像方式的改进，尤其是超声心动图方面的改进，使得对该病患病率的估计更为准确，但仍需对其发病机制、治疗以及与APS的关联进行进一步研究。
