• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

低血糖的简单原因:血管紧张素转换酶抑制剂诱发非糖尿病患者严重复发性低血糖

Simple Reason for Hypoglycemia: ACE Inhibitor-induced Severe Recurrent Hypoglycemia in a Nondiabetic Patient.

作者信息

Elshimy Ghada, Techathaveewat Pawarid, Alsayed Mahmoud, Jyothinagaram Sathya, Correa Ricardo

机构信息

Endocrinology, Diabetes and Metabolism, University of Arizona College of Medicine-Phoenix, Phoenix, USA.

出版信息

Cureus. 2019 Aug 21;11(8):e5449. doi: 10.7759/cureus.5449.

DOI:10.7759/cureus.5449
PMID:31489273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6713252/
Abstract

Angiotensin-converting enzyme (ACE) inhibitors are among the most common medications used to treat patients with concomitant diabetes and hypertension. They are considered the first line of treatment for hypertension in this population. Several case studies have reported that ACE inhibitors can induce hypoglycemia in patients with diabetes. To our knowledge, however, ACE inhibitors have not been found to induce hypoglycemia in patients without diabetes. This report describes a patient without diabetes experiencing recurrent severe hypoglycemia induced by the ACE inhibitor lisinopril.

摘要

血管紧张素转换酶(ACE)抑制剂是治疗糖尿病合并高血压患者最常用的药物之一。它们被认为是该人群高血压治疗的一线用药。多项病例研究报告称,ACE抑制剂可诱发糖尿病患者低血糖。然而,据我们所知,尚未发现ACE抑制剂会在非糖尿病患者中诱发低血糖。本报告描述了一名非糖尿病患者因服用ACE抑制剂赖诺普利而反复出现严重低血糖的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/701c0a4df94c/cureus-0011-00000005449-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/ccd4dc6d8239/cureus-0011-00000005449-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/134060d96b46/cureus-0011-00000005449-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/9517adef9b15/cureus-0011-00000005449-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/942e309c4f21/cureus-0011-00000005449-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/701c0a4df94c/cureus-0011-00000005449-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/ccd4dc6d8239/cureus-0011-00000005449-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/134060d96b46/cureus-0011-00000005449-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/9517adef9b15/cureus-0011-00000005449-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/942e309c4f21/cureus-0011-00000005449-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3a/6713252/701c0a4df94c/cureus-0011-00000005449-i05.jpg

相似文献

1
Simple Reason for Hypoglycemia: ACE Inhibitor-induced Severe Recurrent Hypoglycemia in a Nondiabetic Patient.低血糖的简单原因:血管紧张素转换酶抑制剂诱发非糖尿病患者严重复发性低血糖
Cureus. 2019 Aug 21;11(8):e5449. doi: 10.7759/cureus.5449.
2
ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring Unit.使用血管紧张素转换酶抑制剂与糖尿病患者因严重低血糖住院有关。DARTS/MEMO合作项目。苏格兰泰赛德糖尿病审计与研究。药物监测单位。
Diabetes Care. 1997 Sep;20(9):1363-7. doi: 10.2337/diacare.20.9.1363.
3
An Unexpected Case of Lisinopril-Associated Severe Hyponatremia.一例与赖诺普利相关的严重低钠血症的意外病例。
Cureus. 2020 Jul 7;12(7):e9039. doi: 10.7759/cureus.9039.
4
Angiotensin-converting enzyme insertion/deletion polymorphism and severe hypoglycemia complicating type 2 diabetes: the Fremantle Diabetes Study.血管紧张素转化酶插入/缺失多态性与 2 型糖尿病并发严重低血糖:弗里曼特尔糖尿病研究。
J Clin Endocrinol Metab. 2011 Apr;96(4):E696-700. doi: 10.1210/jc.2010-2087. Epub 2011 Feb 2.
5
The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes.血管紧张素转换酶插入/缺失多态性对2型糖尿病严重低血糖的影响。
Rev Diabet Stud. 2006 Summer;3(2):76-81. doi: 10.1900/RDS.2006.3.76. Epub 2006 Aug 10.
6
Overview of the angiotensin-converting-enzyme inhibitors.血管紧张素转换酶抑制剂概述。
Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. doi: 10.1093/ajhp/57.suppl_1.S3.
7
Prevention of type 2 diabetes mellitus through inhibition of the Renin-Angiotensin system.通过抑制肾素-血管紧张素系统预防2型糖尿病
Drugs. 2004;64(22):2537-65. doi: 10.2165/00003495-200464220-00004.
8
Angiotensin-converting enzyme inhibitors: a comparative review.血管紧张素转换酶抑制剂:一项比较性综述。
DICP. 1990 May;24(5):506-25. doi: 10.1177/106002809002400512.
9
Malignant primary hypertension in pregnancy treated with lisinopril.用赖诺普利治疗的妊娠恶性原发性高血压。
Ann Pharmacother. 2000 Feb;34(2):180-2. doi: 10.1345/aph.19161.
10
Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data.血管紧张素转换酶抑制剂与非糖尿病肾病的进展。患者水平数据的荟萃分析。
Ann Intern Med. 2001 Jul 17;135(2):73-87. doi: 10.7326/0003-4819-135-2-200107170-00007.

引用本文的文献

1
ACE inhibitors and their interaction with systems and molecules involved in metabolism.血管紧张素转换酶抑制剂及其与参与代谢的系统和分子的相互作用。
Heliyon. 2024 Jan 14;10(2):e24655. doi: 10.1016/j.heliyon.2024.e24655. eCollection 2024 Jan 30.
2
Symptomatic Hypoglycemia During Treatment with a Therapeutic Dose of Metformin.治疗剂量二甲双胍治疗期间出现症状性低血糖。
Am J Case Rep. 2021 Jun 2;22:e931311. doi: 10.12659/AJCR.931311.

本文引用的文献

1
Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline.成人低血糖症的评估与管理:内分泌学会临床实践指南
J Clin Endocrinol Metab. 2009 Mar;94(3):709-28. doi: 10.1210/jc.2008-1410. Epub 2008 Dec 16.
2
A signal of increased risk of hypoglycaemia with angiotensin receptor blockers caused by confounding.由混杂因素导致的血管紧张素受体阻滞剂引起低血糖风险增加的信号。
Br J Clin Pharmacol. 2008 Jul;66(1):142-5. doi: 10.1111/j.1365-2125.2008.03176.x. Epub 2008 May 27.
3
Role of the B(2) receptor of bradykinin in insulin sensitivity.
Hypertension. 2001 Dec 1;38(6):1355-60. doi: 10.1161/hy1201.096574.
4
ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring Unit.使用血管紧张素转换酶抑制剂与糖尿病患者因严重低血糖住院有关。DARTS/MEMO合作项目。苏格兰泰赛德糖尿病审计与研究。药物监测单位。
Diabetes Care. 1997 Sep;20(9):1363-7. doi: 10.2337/diacare.20.9.1363.
5
Hypoglycemia associated with the administration of angiotensin-converting enzyme inhibitor in a patient with diabetes mellitus.
Intern Med. 1997 Jan;36(1):77. doi: 10.2169/internalmedicine.36.77.
6
Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme.与使用血管紧张素转换酶抑制剂相关的低血糖症
Lancet. 1995 May 13;345(8959):1195-8. doi: 10.1016/s0140-6736(95)91988-0.
7
Captopril and insulin sensitivity.
Ann Intern Med. 1985 Jan;102(1):134-5. doi: 10.7326/0003-4819-102-1-134_3.
8
Hypoglycemia in hypertensive diabetic patients treated with sulfonylureas, biguanides, and captopril.
N Engl J Med. 1988 Dec 15;319(24):1609. doi: 10.1056/NEJM198812153192417.
9
Angiotensin converting enzyme inhibitors in diabetes: experimental and human experience.
Postgrad Med J. 1986;62 Suppl 1:59-64.
10
Captopril, enalapril, and blood glucose.
Lancet. 1986 May 3;1(8488):1035. doi: 10.1016/s0140-6736(86)91304-8.