Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, India.
Department of Urology, Keck Hospital of USC, Los Angeles, USA.
World J Urol. 2020 Oct;38(10):2651-2660. doi: 10.1007/s00345-019-02934-0. Epub 2019 Sep 5.
The main aim of the paper is to report a single-centre experience with RAKT, focusing on surgical, perioperative and functional outcomes at a median follow-up of 2.8 years.
Data of 26 RAKT patients was prospectively collected from December 2014 to February 2019 with follow-up of up to 55 months. All donors were done laparoscopically. We followed Vattikuti-Medanta technique with modification of using pfannenstiel incision instead of Gelpoint and patient positioned in steep Trendelenburg position (30°) with leg split position. Hypothermia was maintained using a "modified graft hypothermia jacket". The engrafted kidney is oriented with the vessels being tagged with Prolene sutures.
The mean BMI was 26.1 ± 4.7. The mean warm, cold and total ischemia times were 4.8 ± 1.1, 113.8 ± 20.9 and 118.7 ± 21.2 min, respectively. Mean rewarming time was 62.5 ± 10 min. The mean post-operative day (POD) 1, 3, 7, 30, 6 months, 1 year and most recent creatinine was 3.4, 2.4, 1.8, 1.4,1.2, 1.2 and 1.69 mg/dl. There was no case of delayed graft dysfunction (DGF) with graft survival of 1.8-55 months. The mean GFR at POD 1, 1 month and 1 year was 24, 53.16 and 64.6. We had two intraoperative complications-one topsy turvy graft placement with anastomosis of donor ureter to native ureter and other had to be converted to open technique after anastomosis to control graft surface bleeding. Three postoperative complications-one patient has graft pyelonephritis which was managed conservatively with antibiotics. Two patients had lymphocele. One patient was managed with just aspiration while the other required laparoscopic de-roofing of the lymphocele. The mean hospital stay was 13.5 ± 3 days.
RAKT is feasible and safe only if performed by surgeons with appropriate background in robotic surgery and kidney transplantation after proper surgical training at experienced centres in the mid-term follow-up. Further studies need to confirm the long-term safety of RAKT.
本文旨在报告单中心 RAKT 经验,重点介绍中位随访 2.8 年后的手术、围手术期和功能结果。
2014 年 12 月至 2019 年 2 月,前瞻性收集了 26 例 RAKT 患者的数据,随访时间长达 55 个月。所有供者均采用腹腔镜进行。我们遵循 Vattikuti-Medanta 技术,采用改良 Pfannenstiel 切口代替 Gelpoint,并将患者置于倾斜的 Trendelenburg 位置(30°)和腿部分裂位置。使用“改良移植物低温保护套”保持体温。移植肾的方向是用 Prolene 缝线标记血管。
平均 BMI 为 26.1±4.7。平均热缺血、冷缺血和总缺血时间分别为 4.8±1.1、113.8±20.9 和 118.7±21.2 分钟。平均复温时间为 62.5±10 分钟。术后第 1、3、7、30、6 个月、1 年和最近的肌酐分别为 3.4、2.4、1.8、1.4、1.2、1.2 和 1.69mg/dl。无移植肾功能延迟恢复(DGF)病例,移植物存活率为 1.8-55 个月。术后第 1 天、第 1 个月和第 1 年的平均 GFR 分别为 24、53.16 和 64.6。我们有两个术中并发症-一个供体肾位置颠倒,供体输尿管与原输尿管吻合,另一个在吻合后转为开放技术以控制移植物表面出血。三个术后并发症-一名患者发生移植肾肾盂肾炎,经抗生素保守治疗。两名患者发生淋巴囊肿。一名患者仅需抽吸,另一名患者需要腹腔镜去顶术治疗淋巴囊肿。平均住院时间为 13.5±3 天。
只有在具有适当机器人手术背景和在经验丰富的中心接受适当的手术培训后,才能安全地进行 RAKT。中期随访结果表明,RAKT 是可行的。需要进一步的研究来证实 RAKT 的长期安全性。