Department of Internal Medicine & Cardiology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
Cardiol J. 2021;28(3):416-422. doi: 10.5603/CJ.a2019.0086. Epub 2019 Sep 6.
The aim of this study was to evaluate the usefulness of a novel clinical score - the InterTAK Diagnostic Score in differentiating Takotsubo syndrome (TTS) from acute coronary syndrome (ACS).
Medical records of 40 consecutive patients with ACS and 20 patients with TTS were managed and retrospectively analyzed at the documented center. Each patient was evaluated using the Inter- TAK Diagnostic Score. To illustrate the diagnostic ability of the score, a receiver operating characteristic (ROC) curve was performed.
Takotsube syndrome patients were more often female compared to the ACS group (70% vs. 27.5%, p = 0.002), an emotional trigger was more prevalent among the TTS group (65% vs. 7.5%, p < 0.001). The area under the curve (AUC) for the score was 0.885 (95% confidence interval [CI] 0.78-0.97). Using a cut-off value of 45 points, the sum of sensitivity and specificity was the highest. However, when patients with a score of ≥ 50 were diagnosed as TTS, 85% were diagnosed correctly. When patients with score ≤ 31 were diagnosed as ACS, 92% were diagnosed correctly.
The InterTAK Diagnostic Score might help in differentiating TTS from ACSs with high sensitivity and specificity. This finding requires further investigation to confirm its clinical utility.
本研究旨在评估一种新的临床评分——InterTAK 诊断评分在鉴别 Takotsubo 综合征（TTS）与急性冠状动脉综合征（ACS）方面的效用。
在记录中心对连续的 40 例 ACS 患者和 20 例 TTS 患者的病历进行管理和回顾性分析。每位患者均采用 InterTAK 诊断评分进行评估。为了说明评分的诊断能力，进行了受试者工作特征（ROC）曲线分析。
与 ACS 组相比，TTS 组患者更多为女性（70%比 27.5%，p = 0.002），情绪诱因在 TTS 组更为常见（65%比 7.5%，p < 0.001）。评分的曲线下面积（AUC）为 0.885（95%置信区间 [CI] 0.78-0.97）。使用 45 分的截断值，灵敏度和特异性的总和最高。然而，当诊断评分≥50 分的患者被诊断为 TTS 时，85%的诊断是正确的。当诊断评分≤31 分的患者被诊断为 ACS 时，92%的诊断是正确的。
InterTAK 诊断评分有助于鉴别 TTS 与 ACS，具有较高的灵敏度和特异性。这一发现需要进一步研究以确认其临床实用性。
