Shams-Rad Shamim, Mohammadi Mohammad, Ramezani-Jolfaie Nahid, Zarei Sadegh, Mohsenpour Mohammadali, Salehi-Abargouei Amin
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Br J Clin Pharmacol. 2020 Jan;86(1):13-22. doi: 10.1111/bcp.14120. Epub 2019 Dec 12.
To the best of our knowledge, no study has tried to quantitatively summarize the published evidence regarding the effect of hesperidin supplementation on blood glucose control. The present systematic review and meta-analysis of randomized controlled trials aimed to determine the effectiveness of hesperidin supplementation in improving blood glucose control in adults.
Electronic databases including PubMed, ISI Web of Science, Scopus, and Google Scholar were searched up to February 2019. The risk of bias in individual studies was assessed using the Cochrane collaboration's tool. The overall estimates and their 95% confidence intervals (CIs) were calculated using a random-effects model.
Six trials with 318 participants were reviewed in the present systematic review. The results showed that hesperidin had no significant effect on serum fasting blood glucose (weighted mean difference [WMD] = -1.10 mg/dL, 95% CI: -3.79, 1.57), plasma insulin (WMD = -0.01 μU/mL, 95% CI: -1.20, 1.19), glycated haemoglobin A1c (WMD = -0.04%, 95% CI: -0.14, 0.04), homeostasis model assessment for insulin resistance (WMD = 0.117, 95% CI: -0.06, 0.29) and quantitative insulin sensitivity check index (WMD = 0.135; 95% CI: -0.13, 0.39), with no significant between-study heterogeneity. Subgroup analyses also indicated that the effects were not different based on the studies' design and duration, or the health status of the participants.
Although several animal studies have proposed that hesperidin supplementation might improve blood glucose control, the present study could not confirm this benefit in humans.
据我们所知，尚无研究试图定量总结已发表的关于补充橙皮苷对血糖控制影响的证据。本项随机对照试验的系统评价和荟萃分析旨在确定补充橙皮苷对改善成人血糖控制的有效性。
检索了包括PubMed、ISI科学网、Scopus和谷歌学术在内的电子数据库，检索截至2019年2月的数据。使用Cochrane协作组的工具评估单个研究的偏倚风险。采用随机效应模型计算总体估计值及其95%置信区间（CI）。
本项系统评价纳入了6项试验，共318名参与者。结果显示，橙皮苷对血清空腹血糖（加权平均差[WMD]=-1.10mg/dL，95%CI：-3.79，1.57）、血浆胰岛素（WMD=-0.01μU/mL，95%CI：-1.20，1.19）、糖化血红蛋白A1c（WMD=-0.04%，95%CI：-0.14，0.04）、胰岛素抵抗稳态模型评估（WMD=0.117，95%CI：-0.06，0.29）和定量胰岛素敏感性检查指数（WMD=0.135；95%CI：-0.13，0.39）均无显著影响，研究间无显著异质性。亚组分析还表明，根据研究设计、持续时间或参与者的健康状况，其效果并无差异。
尽管多项动物研究表明补充橙皮苷可能改善血糖控制，但本研究未能证实其对人类有此益处。
