Satheesh Naik K, Gurushanthaiah M, Kavimani M, Prabhu K, Lokanadham S
Department of Anatomy, Bharath University (BIHER), Chennai, Tamilnadu, India.
Department of Anatomy, Basaveshwara Medical College, Chitradurga, Karnataka, India.
Maedica (Bucur). 2018 Sep;13(3):217-222. doi: 10.26574/maedica.2018.13.3.217.
The hepatic injury due to oxidative stress was ameliorated through administration of an aqueous extract of Eclipta alba leaves and suggested that wedelolactone and demethylwedelolactone were the possible components of Eclipta alba behind the protective effect on liver as well as against liver disorders.
To study the hepato-protective effects of Eclipta alba on high fatty diet treated experimental models.
A total of 30 adult albino rats of Wistar strain weighing 165-215 grams, from the animal house of the Basaveshwara Medical College, Hospital and Research Centre, Chitradurga, were used for the present study: group 1 included animals fed with normal diet (control); group 2, animals treated with hyperlipidemic diet for eight weeks; group 3, animals treated with hyperlipidemic diet for eight weeks, followed by one week post treatment of Eclipta alba with normal diet; group 4, animals treated with hyperlipidemic diet for eight weeks, followed by two weeks post-treatment of Eclipta alba with normal diet; and group 5, animals treated with hyperlipidemic diet for eight weeks, followed by three weeks posttreatment of Eclipta alba with normal diet.
In animals with high fat diet (30%), we observed the deposition of fat in the form of fat lobules in and around the hepatocytes, mononuclear in filtration in the liver parenchyma, dilation of blood vessels, necrotic foci and damaged hepatocytes.
The components of Eclipta alba like wedelolactone, demethylwedelolactone and saponins reduced fat deposition, mononuclear infiltration, and necrotic foci, and stimulated hepatocyte regeneration in the liver.
通过给予白花蟛蜞菊叶水提取物，可减轻氧化应激所致的肝损伤，提示去甲蟛蜞菊内酯和蟛蜞菊内酯可能是白花蟛蜞菊对肝脏起保护作用及预防肝脏疾病的有效成分。
研究白花蟛蜞菊对高脂饮食处理的实验模型的肝脏保护作用。
本研究选用了30只体重在165 - 215克之间的成年Wistar品系白化大鼠，这些大鼠来自奇特拉杜尔加的巴萨韦什瓦拉医学院、医院及研究中心的动物房：第1组为喂食正常饮食的动物（对照组）；第2组为接受高脂饮食8周的动物；第3组为接受高脂饮食8周，之后用正常饮食给予白花蟛蜞菊治疗1周的动物；第4组为接受高脂饮食8周，之后用正常饮食给予白花蟛蜞菊治疗2周的动物；第5组为接受高脂饮食8周，之后用正常饮食给予白花蟛蜞菊治疗3周的动物。
在高脂饮食的动物（30%）中，我们观察到肝细胞内及周围出现脂肪小叶形式的脂肪沉积、肝实质内单核细胞浸润、血管扩张、坏死灶和受损肝细胞。
白花蟛蜞菊的成分如去甲蟛蜞菊内酯、蟛蜞菊内酯和皂苷可减少脂肪沉积、单核细胞浸润和坏死灶，并刺激肝脏中的肝细胞再生。
