Exponent, Inc., Menlo Park, California (Dr Fordyce and Dr Mowat); Exponent, Inc., Bellevue, Washington (Dr Leonhard and Dr Moolgavkar).
J Occup Environ Med. 2019 Nov;61(11):916-923. doi: 10.1097/JOM.0000000000001700.
The aim of this study was to update a cohort of Vermont talc workers to include 37 additional years of follow-up time.
Standardized mortality ratios (SMR) and 95% confidence intervals (CIs) were calculated for 70+ causes of death. US population mortality rates were used as reference.
All-cause mortality was 30% higher than the US population (SMR 133.4, 95% CI, 119.7 to 148.3). Significant elevations occurred in nonmalignant respiratory disease (NMRD) (SMR 273.0, 95% CI, 210.2 to 348.6) and other nonmalignant respiratory disease (ONMRD) (SMR 413.1, 95% CI, 287.7 to 574.5). ONMRD was elevated across all length of employment categories and a test for linear trend was significant (P = 0.007).
This study provides further evidence that excess deaths among Vermont talc workers are due largely to excess mortality from NMRD; there is no evidence of increased risk of respiratory cancer.
本研究旨在对佛蒙特州滑石粉工人队列进行更新，增加 37 年的随访时间。
计算了 70 多种死因的标准化死亡率（SMR）和 95%置信区间（CI）。使用美国人口死亡率作为参考。
全因死亡率比美国人口高 30%（SMR 133.4，95%CI，119.7 至 148.3）。非恶性呼吸道疾病（NMRD）（SMR 273.0，95%CI，210.2 至 348.6）和其他非恶性呼吸道疾病（ONMRD）（SMR 413.1，95%CI，287.7 至 574.5）显著升高。ONMRD 在所有就业年限类别中均升高，线性趋势检验具有统计学意义（P=0.007）。
本研究进一步证明，佛蒙特州滑石粉工人的超额死亡主要归因于 NMRD 导致的超额死亡率；没有证据表明呼吸癌的风险增加。
