滑石粉吸入在大鼠和人体中的研究：现有证据的回顾和评估。
Talc Inhalation in Rats and Humans: A Review and Appraisal of Available Evidence.
机构信息
From the Nanoconsult Holding BV, Meerssen (NL).
出版信息
J Occup Environ Med. 2023 Feb 1;65(2):152-159. doi: 10.1097/JOM.0000000000002702. Epub 2022 Sep 12.
Abstract
BACKGROUND
Current information on the health effects and toxicology of talc suggests that this may lead to a specific target organ toxicity arising from repeated exposure (STOT-RE) classification.
OBJECTIVE
To provide an assessment of the currently available inhalation toxicity data on talc and to put these data in the perspective of other poorly soluble low-toxicity particles.
METHODS
A database of 177 articles was gathered from different sources.
RESULTS
Relevant animal data sets were subjected to a quality review, and epidemiological studies on talc and lung effects published since 2016 were reviewed.
CONCLUSIONS
Of nine original inhalation studies reviewed, only one study using rats and mice met the criteria that are needed to include for a reliable evaluation for STOT-RE. Together with the pulmonary effects observed in exposed talc miners, a STOT-RE 1 classification is warranted.
摘要
背景
目前有关滑石粉对健康的影响和毒理学的信息表明，这可能导致源于反复暴露的特定靶器官毒性（STOT-RE）分类。
目的
对目前可获得的关于滑石粉吸入毒性的数据进行评估，并将这些数据与其他难溶性低毒性颗粒的数据进行比较。
方法
从不同来源收集了一个包含 177 篇文章的数据库。
结果
对相关的动物数据集进行了质量审查，并对 2016 年以来发表的关于滑石粉和肺部影响的流行病学研究进行了审查。
结论
在所审查的九项原始吸入研究中，只有一项使用大鼠和小鼠的研究符合纳入 STOT-RE 可靠评估所需的标准。结合暴露于滑石粉矿工的肺部影响，有理由将 STOT-RE 分类为 1 类。
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