Addiction Center, Keyo Hospital, Ojeon-ro, Uiwang-city, Gyeonggi-do, Republic of Korea.
Division of Pulmonology, Department of Internal Medicine, The Cancer Research Institute, College of Medicine, The Catholic University of Korea, Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
PLoS One. 2019 Sep 6;14(9):e0220127. doi: 10.1371/journal.pone.0220127. eCollection 2019.
Tobacco use disorder (TUD), previously known as nicotine dependence, was associated with increased risk of lung cancer. However, little is known about the prevalence of TUD and symptom manifestation in smokers with lung cancer.
The aim of the present study was to investigate the prevalence of TUD using DSM-5 diagnostic criteria in patients diagnosed with lung cancer and analyze their tobacco use characteristics.
A total of 200 histologically confirmed lung cancer patients who used tobacco within the prior 12-month period at the time of diagnosis were recruited for this study. Participants were assessed using interviewer-administered questionnaires to determine TUD symptoms and smoking-related behaviors, and self-administered Fagerstrom Test for Nicotine Dependence (FTND) was also administered.
The prevalence of DSM-5 TUD was 92.0% (n = 184). Of a total of 200 subjects, 23 (11.5%), 35 (17.5%), and 126 (63.0%) were classified into mild, moderate, and severe TUD categories, respectively. A total of 19 (81.3%) moderate TUD and 98 (77.8%) severe TUD patients had attempted smoking cessation. Of these subjects, 21 (21.4%) severe TUD and 12 (63.2%) moderate TUD patients tried more than three times. The number of satisfied criteria under DSM-5 TUD was positively correlated with FTND score, cumulative lifetime smoking amount, and daily smoking levels.
Smokers diagnosed with lung cancer showed a high prevalence of DSM-5 TUD. Their heavy and consistent tobacco use suggests reduced motivation to abstain from smoking.
烟草使用障碍（TUD），以前称为尼古丁依赖，与肺癌风险增加有关。然而，对于患有肺癌的吸烟者中 TUD 的患病率和症状表现知之甚少。
本研究旨在使用 DSM-5 诊断标准调查诊断为肺癌的患者中 TUD 的患病率，并分析其烟草使用特征。
共招募了 200 名在诊断前 12 个月内有吸烟史的组织学确诊肺癌患者。通过访谈者管理的问卷评估参与者，以确定 TUD 症状和吸烟相关行为，并进行自我管理的尼古丁依赖 Fagerstrom 测试（FTND）。
DSM-5 TUD 的患病率为 92.0%（n=184）。在总共 200 名受试者中，23 名（11.5%）、35 名（17.5%）和 126 名（63.0%）分别归类为轻度、中度和重度 TUD 类别。共有 19 名（81.3%）中度 TUD 和 98 名（77.8%）重度 TUD 患者尝试过戒烟。在这些受试者中，21 名（21.4%）重度 TUD 和 12 名（63.2%）中度 TUD 患者尝试过超过三次。DSM-5 TUD 下符合标准的数量与 FTND 评分、累积终生吸烟量和每日吸烟水平呈正相关。
诊断为肺癌的吸烟者表现出 DSM-5 TUD 的高患病率。他们大量且持续的吸烟表明戒烟的动机降低。
