Geneva Cancer Registry, Global Health Institute, University of Geneva, Geneva, Switzerland.
Service of Oncology, Geneva University Hospitals, Geneva, Switzerland.
PLoS One. 2019 Sep 6;14(9):e0222136. doi: 10.1371/journal.pone.0222136. eCollection 2019.
Breast cancer is the most frequently diagnosed cancer among women worldwide. Despite the fact that breast cancer is more frequent after fifty years of age, breast cancer among young women has recently drawn particular attention due to an increase in incidence in several western countries. With the exception of individuals with a high genetic risk, breast cancer occurring in younger women remains poorly understood. This project aims at investigating the patient, tumour and treatment characteristics as well as the long-term health outcomes of these women by evaluating numerous variables that were collected from their pathology and medical files, including the social environment, family history, fertility and pregnancy.
We constituted a population-based cohort from the Geneva Cancer Registry of 1586 patients with breast cancer who were aged less than 46 years at the time of diagnosis.
Breast cancer was diagnosed before the age of 35 years in 225 women (14.2%), between 35 and 39 years of age in 368 women (23.2%) and between 40 and 45 years of age in 993 women (62.6%). Most of the patients were diagnosed with luminal A or luminal B molecular subtypes (32.8 and 37.5%, respectively), stage I or II tumours (75.2%), and estrogen (74.8%) and progesterone (67.5%) positive receptors. During the study period, 16.7% of these women developed loco-regional recurrences and 25.4% developed distant metastases; the majority (66.3%) did not have a recurrence. Regarding mortality, 474 (29.9%) women died during the study period, 347 (73.2%) from breast cancer.
The results of this study will help filling the knowledge gap about treatment of young breast cancer patients and having a child after breast cancer, and will provide clinicians and public health professionals' with additional information to improve quality of care and decrease the impact of breast cancer in young women.
乳腺癌是全球女性中最常见的癌症。尽管乳腺癌在五十岁以后更为常见，但由于在一些西方国家发病率上升，年轻女性的乳腺癌最近引起了特别关注。除了遗传风险高的个体外，年轻女性的乳腺癌仍然知之甚少。本项目旨在通过评估从患者的病理和医疗档案中收集的大量变量，包括社会环境、家族史、生育和妊娠，研究这些女性的患者、肿瘤和治疗特征以及长期健康结果。
我们从日内瓦癌症登记处建立了一个基于人群的队列，其中包括 1586 名年龄在诊断时小于 46 岁的乳腺癌患者。
225 名女性（14.2%）在 35 岁之前被诊断出患有乳腺癌，368 名女性（23.2%）在 35 至 39 岁之间被诊断出患有乳腺癌，993 名女性（62.6%）在 40 至 45 岁之间被诊断出患有乳腺癌。大多数患者被诊断为 luminal A 或 luminal B 分子亚型（分别为 32.8%和 37.5%）、I 期或 II 期肿瘤（75.2%）以及雌激素（74.8%）和孕激素（67.5%）阳性受体。在研究期间，这些女性中有 16.7%发生局部区域复发，25.4%发生远处转移；大多数（66.3%）没有复发。至于死亡率，在研究期间，474 名（29.9%）女性死亡，其中 347 名（73.2%）死于乳腺癌。
本研究的结果将有助于填补年轻乳腺癌患者治疗和乳腺癌后生育的知识空白，并为临床医生和公共卫生专业人员提供更多信息，以改善护理质量并降低年轻女性乳腺癌的影响。
