羟基酪醇、羟基酪醇乙酸酯和 3,4-二羟基苯乙二醇的三步、克级合成。
A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol.
机构信息
Division of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Division of Pharmacognosy & Natural Product Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
出版信息
Molecules. 2019 Sep 5;24(18):3239. doi: 10.3390/molecules24183239.
Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation.
羟基酪醇和橄榄树的另外两种多酚，羟基酪醇乙酸酯和 3,4-二羟基苯乙二醇，因其在人类健康和疾病预防方面的广泛有益作用而闻名。由于无法分离出这些天然化合物的高纯度量，以及它们的合成过程困难且繁琐，我们在这里描述了一种从儿茶酚通过微波辐射进行高效、简单、廉价和规模化合成的方法。
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