Correia Bruna L, Gomes Ana T P C, Noites Rita, Ferreira José M F, Duarte Ana S
Department of Materials and Ceramic Engineering, CICECO-Aveiro Institute of Materials, Campus Santiago, University of Aveiro, 3810-193 Aveiro, Portugal.
Universidade Católica Portuguesa, Faculdade de Medicina Dentária, Centro de Investigação Interdisciplinar em Saúde, 3504-505 Viseu, Portugal.
Nanomaterials (Basel). 2022 May 6;12(9):1577. doi: 10.3390/nano12091577.
Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol-gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments ( and ) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of after 48 h of incubation, and all BG samples have a significant effect on survival.
牙髓治疗旨在通过去除感染组织、消毒以及填充/封闭根管来保留牙齿。最重要的治疗步骤之一是清除微生物，以避免再次感染和随之而来的牙齿脱落。由于对根管内药物的耐药性增加，需要新的替代程序。因此，建议使用通过溶胶-凝胶法制备的三种生物活性玻璃（BG）组合物（BG1、BG2和BG3）进行根管内用药，它们具有不同摩尔含量的杀菌氧化物。对这些生物活性玻璃进行了形态学和物理表征。还研究了它们抑制两种导致牙髓治疗失败的口腔病原体（ 和 ）生长的能力。结果表明，在培养48小时后，BG2和BG3可以抑制 的生长，并且所有BG样品对 的存活都有显著影响。
