Galton Laboratory, Department practice guidelinesof Genetics, Evolution and Environment, University College London, United Kingdom.
Department of Paediatrics, Medical School, Mater Dei Hospital, Malta.
Early Hum Dev. 2020 Jan;140:104862. doi: 10.1016/j.earlhumdev.2019.104862. Epub 2019 Sep 3.
A recent study has attempted to estimate the primary sex ratio i.e. the sex ratio at conception, using a variety of studies in the extant literature. Starting with data at birth, the authors projected back in time, estimating foetal loss at each gestational stage. Their overall conclusion was that there are equal numbers of males and females formed at conception. This paper contradicts these estimates using two very large samples of accurately recorded 19th century births. These datasets come from a time when contraception and sex selection were not widely practised. The conclusions are that at the time of conception, there is a substantial excess of males, the excess probably being determined by the hormone levels of both parents in accord with the hormonal hypothesis, and if conditions during pregnancy are stressful, then frail male foetuses will preferentially be culled. In short, more males than females are conceived, and that more males are miscarried, and that more males still survive to birth.
最近的一项研究试图通过对现有文献中的各种研究进行评估,来估算主要性别比例,即受孕时的性别比例。研究人员从出生时的数据开始,回溯时间,估算每个妊娠阶段的胎儿损失。他们的总体结论是,在受孕时形成的男性和女性数量相等。本文使用两个非常大的、记录准确的 19 世纪出生样本数据来反驳这些估计。这些数据集来自于避孕和性别选择尚未广泛应用的时期。研究结论是,在受孕时,男性数量明显过多,这种过剩可能是由父母双方的激素水平决定的,符合激素假说,如果怀孕期间的条件有压力,那么脆弱的男性胎儿将被优先淘汰。简而言之,受孕时的男婴比女婴多,而且男婴流产的比例更高,还有更多的男婴能够存活到出生。