Faculty of Medicine, University of Rzeszow, Rzeszow, Poland.
Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland.
Sci Rep. 2019 Sep 6;9(1):12857. doi: 10.1038/s41598-019-49326-3.
Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.
套细胞淋巴瘤（MCL）被认为是一种无法治愈的肿瘤，即使采用新的药物策略也是如此。众所周知，MCL 有两种形态变体——经典型和侵袭性。与经典亚型相比，侵袭性 MCL 的特点是有更高的有丝分裂指数和增殖率，以及更差的整体存活率。深入了解 MCL 的详细生化组成对于进一步制定 MCL 患者的诊断和治疗指南至关重要；因此，使用同步辐射傅里叶变换红外（S-FTIR）显微光谱学结合主成分分析（PCA）。在蛋白质和核酸含量方面观察到了主要的光谱差异，揭示了经典和侵袭性 MCL 的分类方案。结果表明，FTIR 显微光谱学反映了两种 MCL 亚型的组织病理学差异。
