Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Trends Pharmacol Sci. 2019 Oct;40(10):714-716. doi: 10.1016/j.tips.2019.08.007. Epub 2019 Sep 5.
Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.
过敏反应是一种危及生命的过敏反应，依赖于高亲和力过敏原特异性 IgE。Gowthaman 等人现在表明，一种新的表达白细胞介素 (IL)-13 的辅助性 T 细胞亚群特异性促进高亲和力 IgE 反应。滤泡辅助性 T 细胞 (Tfh)13 细胞的发现为过敏治疗提供了新的潜在靶点。
