Sinzinger H, Gisslinger H, Linkesch W, Ludwig H, Flener R, Peskar B A
II. Medizinische Universitätsklinik, Wien.
Wien Klin Wochenschr. 1988 Nov 4;100(21):715-8.
In 2 out of 29 patients suffering from the myeloproliferative syndrome a lack of thromboxane conversion by platelets from exogenous arachidonic acid was discovered. In one patient PGE2 (30.9%) and 12-HETE (12-Hydroxyeicosatetraenoic acid) (42.8%) were formed instead, whilst in the other patient 12-HETE (72.9%) was the main metabolic product. In both the patients, serum and plasma TXB2, as well as malondialdehyde, were quite low. It is claimed that this phenomenon is due to the expression of a pathological population of platelets related to the disease.
在29例骨髓增殖综合征患者中，有2例被发现血小板无法将外源性花生四烯酸转化为血栓素。在1例患者中，取而代之生成了前列腺素E2（30.9%）和12-羟基二十碳四烯酸（12-HETE）（42.8%），而在另1例患者中，12-羟基二十碳四烯酸（72.9%）是主要代谢产物。这2例患者的血清和血浆血栓素B2以及丙二醛水平均相当低。据称，这种现象是由于与该疾病相关的病理性血小板群体的表达所致。
