The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
Nat Prod Res. 2021 Jun;35(12):2028-2036. doi: 10.1080/14786419.2019.1655412. Epub 2019 Sep 9.
One new naturally occurring quinone, 3',4'-dihydroxy-1,2,6-trimethoxy-[1,1'-biphenyl]-4(1)-one (), one new diarylpropane, emarginone A (), and one new neolignan, emarginone B (), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the whole plant methanolic extract. The new structures were elucidated by combined analysis of spectroscopic analytical methods and comparison with the literature data obtained from known analogues. In addition, the cytotoxicity of compounds , , and against Du145 and PC-3 prostate cancer cell lines using MTT cell proliferation assay was evaluated. Compounds and showed most potent cytotoxicity against Du145 with IC values of 7.53 and 6.63 μg/mL, respectively. Furthermore, compounds , , and also exhibited significant cytotoxicity against PC-3 with IC values ranging from 3.44-6.64 μg/mL.
从全植物甲醇提取物的乙酸乙酯可溶部分的化学研究中，分离得到一个新的天然醌，3'，4'-二羟基-1,2,6-三甲氧基-[1,1'-联苯]-4(1)-酮（），一个新的二芳基丙烷，凹缘酮 A（），和一个新的新木脂素，凹缘酮 B（），以及十八个已知化合物。新结构通过光谱分析方法的综合分析和与文献数据的比较来阐明，这些数据来自已知类似物。此外，通过 MTT 细胞增殖试验评估了化合物、和对 Du145 和 PC-3 前列腺癌细胞系的细胞毒性。化合物和对 Du145 表现出最强的细胞毒性，IC 值分别为 7.53 和 6.63μg/mL。此外，化合物、和对 PC-3 也表现出显著的细胞毒性，IC 值范围为 3.44-6.64μg/mL。
