Phenylpropanoids and lignoids from the whole plant of and their cytotoxicity against prostate cancer cells.

One new naturally occurring quinone, 3',4'-dihydroxy-1,2,6-trimethoxy-[1,1'-biphenyl]-4(1)-one (), one new diarylpropane, emarginone A (), and one new neolignan, emarginone B (), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the whole plant methanolic extract. The new structures were elucidated by combined analysis of spectroscopic analytical methods and comparison with the literature data obtained from known analogues. In addition, the cytotoxicity of compounds , , and against Du145 and PC-3 prostate cancer cell lines using MTT cell proliferation assay was evaluated. Compounds and showed most potent cytotoxicity against Du145 with IC values of 7.53 and 6.63 μg/mL, respectively. Furthermore, compounds , , and also exhibited significant cytotoxicity against PC-3 with IC values ranging from 3.44-6.64 μg/mL.