Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Graduate University of Science and Technology, VAST, Hanoi, Vietnam.
Nat Prod Res. 2021 Jul;35(13):2123-2130. doi: 10.1080/14786419.2019.1662007. Epub 2019 Sep 9.
Four new prenylated flavonoids, macarindicins I-IV () together with ten known compounds, broussoflavonol F (), vedelianin (), schweinfurthin E (), vitexin (), 2″-rhamnosyl vitexin (), isovitexin (), (6,7,9)-9-hydroxy-megastigman-4,7-dien-3-one-9---D-glucopyranoside (), 6,9)-roseoside (), (6,9)-roseoside (), and bridelionoside B () were isolated from the leaves of Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All the isolated compounds were evaluated for their cytotoxic activities against four human cancer cell lines including KB, MCF-7, HepG-2, and LU. As a result, compound significantly exhibited cytotoxic activity against all tested human cancer cell lines with IC values ranging from 4.7 to 11.0 μM. Compounds , , and showed moderate cytotoxic activity with IC values ranging from 7.0 to 38.7 μM.
从 叶片中分离得到四个新的prenylated 类黄酮，macarindicins I-IV () ，以及十个已知化合物，broussoflavonol F (), vedelianin (), schweinfurthin E (), vitexin (), 2″-rhamnosyl vitexin (), isovitexin (), (6,7,9)-9-hydroxy-megastigman-4,7-dien-3-one-9---D-glucopyranoside (), 6,9)-roseoside (), (6,9)-roseoside () 和 bridelionoside B ()。它们的结构是根据广泛的光谱方法确定的，包括 1D-、2D-NMR 和 MS 数据。所有分离得到的化合物都进行了细胞毒性活性评价，包括 KB、MCF-7、HepG-2 和 LU 四种人类癌细胞系。结果表明，化合物 对所有测试的人类癌细胞系均具有显著的细胞毒性活性，IC 值范围为 4.7 至 11.0 μM。化合物 、 、和 具有中等细胞毒性活性，IC 值范围为 7.0 至 38.7 μM。
