Ranges G E, Fortin S, Barger M T, Sriram S, Cooper S M
Department of Medicine, University of Vermont College of Medicine, Burlington 05405.
Int Rev Immunol. 1988 Sep;4(1):83-90. doi: 10.3109/08830188809044772.
The effects of in vivo modulation of murine collagen induced arthritis with monoclonal anti-CD4 antibodies, monoclonal anti-Ia antibodies, and gamma interferon are reviewed. We detail the mechanism of action of monoclonal anti-CD4 antibody on humoral and cell mediated immune responses and discuss the implications for designing therapeutic strategies. To further explore the induction of collagen induced arthritis, a syngeneic cell transfer system using collagen primed T lymphocytes is described. This cell transfer system provides an opportunity to study the role of CD4 positive T lymphocytes in arthritis induction during a short, defined time period.
综述了用单克隆抗CD4抗体、单克隆抗Ia抗体和γ干扰素对小鼠胶原诱导性关节炎进行体内调节的效果。我们详细阐述了单克隆抗CD4抗体对体液免疫和细胞介导免疫反应的作用机制，并讨论了其对设计治疗策略的意义。为了进一步探究胶原诱导性关节炎的诱导过程，描述了一种使用经胶原致敏的T淋巴细胞的同基因细胞转移系统。该细胞转移系统提供了一个机会，可在一个短暂、明确的时间段内研究CD4阳性T淋巴细胞在关节炎诱导中的作用。
