Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H
Arthritis Rheum. 1986 Mar;29(3):400-10. doi: 10.1002/art.1780290314.
Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but in no case did it give rise to full-blown arthritis.
对20种与II型胶原反应的单克隆抗体的决定簇特异性及其与软骨衍生成分的反应性进行了表征。这些单克隆抗体与天然II型胶原三螺旋结构上的7个不同表位发生反应。定义其中3个表位的抗体在关节炎小鼠血清中出现的频率高于非关节炎小鼠血清。体内注射一些选定的自身反应性抗体可引起滑膜炎，但在任何情况下都不会引发典型的关节炎。
