Lee Yu, Lin Pao-Yen, Lin Meng-Chih, Wang Chin-Chou, Lu Hung-I, Chen Yung-Che, Chong Mian-Yoon, Hung Chi-Fa
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Kaohsiung, Taiwan.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, Kaohsiung, Taiwan.
Cancer Manag Res. 2019 Aug 9;11:7587-7596. doi: 10.2147/CMAR.S188926. eCollection 2019.
The aim of this study was to assess morbidity and associated factors in patients with lung cancer (LC).
This study used a cross-sectional design with consecutive sampling. Study subjects were recruited from the LC outpatient clinic and inpatient ward in a medical center from March 2016 to February 2018. Patients with LC were enrolled and assessed using the Mini International Neuropsychiatric Interview, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Brief Fatigue Inventory, Numeric Pain Rating Scale, and the List of Threatening Experiences Questionnaire.
One hundred and four patients were included in the study. The most prevalent psychiatric disorder was depressive disorder (25.0%), followed by adjustment disorder (17.3%), alcohol use disorder (3.8%), and insomnia disorder (3.8%). Fifty percent of patients had a psychiatric diagnosis. Using logistic regression analysis, it was found that severity of fatigue (OR=1.77; 95% CI, 1.03-3.03; <0.05), severity of stressor (OR=14.14; 95% CI, 2.49-80.20; <0.05), and severity of anxiety (OR=3.75; 95% CI, 1.87-7.54; <0.001) were three significant associated factors. Patient health problems, death of a close family member or friend, and major financial crisis were the three most common stressors among our cancer patients.
Use of a standardized structured interview for early diagnosis and treatment of cancer patients with depressive disorder is crucial and might increase their quality of life.
本研究旨在评估肺癌（LC）患者的发病率及相关因素。
本研究采用连续抽样的横断面设计。研究对象于2016年3月至2018年2月从某医疗中心的肺癌门诊和住院病房招募。纳入肺癌患者并使用迷你国际神经精神病学访谈、汉密尔顿抑郁量表、汉密尔顿焦虑量表、简明疲劳量表、数字疼痛评分量表和威胁性经历问卷清单进行评估。
104例患者纳入本研究。最常见的精神障碍是抑郁症（25.0%），其次是适应障碍（17.3%）、酒精使用障碍（3.8%）和失眠障碍（3.8%）。50%的患者有精神疾病诊断。采用逻辑回归分析发现，疲劳严重程度（OR=1.77；95%CI，1.03 - 3.03；<0.05）、应激源严重程度（OR=14.14；95%CI，2.49 - 80.20；<0.05）和焦虑严重程度（OR=3.75；95%CI，1.87 - 7.54；<0.001）是三个显著的相关因素。患者健康问题、亲密家庭成员或朋友死亡以及重大金融危机是我们癌症患者中最常见的三个应激源。
使用标准化结构化访谈对患有抑郁症的癌症患者进行早期诊断和治疗至关重要，可能会提高他们的生活质量。
