Nasser Hebatallah Ahmed, Ezz Nermeen Zakaria Abuel, Abdel-Mageed Heidi Mohamed, Radwan Rasha Ali
Microbiology & Public Health Department, Faculty of Pharmacy and Drug Technology, Heliopolis University, Heliopolis, Egypt.
Biochemistry Department, College of Pharmaceutical Sciences & Drug Manufacturing, Misr University for Science and Technology, Cairo, Egypt.
J Med Biochem. 2019 Mar 26;38(4):427-436. doi: 10.2478/jomb-2019-0012. eCollection 2019 Oct.
Recent studies suggest asthma prevalence in polycystic ovary syndrome (PCOS) patients. This is the first study to explore asthma prevalence among Egyptian PCOS patients. It highlighted common findings in PCOS and asthma. It investigated whether these findings could serve as potential predictors of asthma.
A hundred PCOS patients, sixty asthmatic patients and thirty apparently healthy females of matched age were included. Body mass index (BMI), C-reactive protein (CRP), IL-6, IgE, 25 (OH) vitamin D, testosterone and lipid profile were measured.
Both PCOS and asthmatics had significantly higher BMI, Total cholesterol (TC), LDL-C, IgE, CRP and IL-6 (P<0.001) and lower 25 (OH) vitamin D levels (P<0.001) compared to controls. Within the PCOS group, 47 patients developed asthma with a significant increase in BMI (P=0.003), CRP and IgE levels (P<0.001) compared to non-asthmatic PCOS. Both asthmatic PCOS and asthmatics expressed elevated BMI, IgE, IL-6 and CRP levels, but with no significant difference between them. Asthmatic PCOS showed significantly higher testosterone and dyslipidemia profile. Multivariate regression revealed that BMI and CRP could predict asthma development within PCOS (OR=1.104, C.I 1.004-1.2 and OR=1, C.I. 1-1.02), respectively. Receiver operating characteristic (ROC) curve showed that BMI and CRP at a cutoff value 28.5 kg/m and 117.6 nmol/L respectively could differentiate between asthmatic and non-asthmatic PCOS with sensitivity 63.8 % and specificity 62% for BMI, and sensitivity and specificity of 66% for CRP.
This study shows that BMI and CRP are predictors of asthma development in Egyptian PCOS.
近期研究提示多囊卵巢综合征（PCOS）患者中哮喘患病率较高。本研究是首次探索埃及PCOS患者中哮喘患病率的研究。该研究突出了PCOS和哮喘的共同发现，并调查了这些发现是否可作为哮喘的潜在预测指标。
纳入100例PCOS患者、60例哮喘患者和30例年龄匹配的明显健康女性。测量体重指数（BMI）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、免疫球蛋白E（IgE）、25（OH）维生素D、睾酮和血脂谱。
与对照组相比，PCOS患者和哮喘患者的BMI、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、IgE、CRP和IL-6均显著升高（P<0.001），而25（OH）维生素D水平显著降低（P<0.001）。在PCOS组中，47例患者发生哮喘，与非哮喘PCOS患者相比，其BMI（P=0.003）、CRP和IgE水平显著升高（P<0.001）。哮喘PCOS患者和哮喘患者的BMI、IgE、IL-6和CRP水平均升高，但两者之间无显著差异。哮喘PCOS患者的睾酮和血脂异常情况显著更高。多因素回归分析显示，BMI和CRP可分别预测PCOS患者哮喘的发生（OR=1.104，可信区间1.004-1.2；OR=1，可信区间1-1.02）。受试者工作特征（ROC）曲线显示，BMI和CRP的临界值分别为28.5 kg/m²和117.6 nmol/L时，可区分哮喘和非哮喘PCOS患者，BMI的敏感性为63.8%，特异性为62%，CRP的敏感性和特异性均为66%。
本研究表明，BMI和CRP是埃及PCOS患者哮喘发生的预测指标。
