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高安动脉炎:大血管血管炎时肾小球会出现什么问题?一例高安动脉炎患者持续性镜下血尿罕见病因的病例报告

Takayasu Arteritis: What Can Go Wrong in The Glomeruli for Large Vessel Vasculitis? A Case Report of an Unusual Cause of Persistent Microscopic Hematuria in a Patient with Takayasu Arteritis.

作者信息

Lai Boon Cheok, Ye QinHao Jonathan, Aung Tin Kyaw Kyaw

机构信息

Internal Medicine, Sengkang General Hospital, Singapore, SGP.

出版信息

Cureus. 2019 Jun 28;11(6):e5024. doi: 10.7759/cureus.5024.

Abstract

We describe a case of persistent microscopic hematuria in a patient with Takayasu arteritis (TA). Urological cause has been excluded. Classically, TA is found to only involve large arteries like the aorta and its branches. There is some evidence that showed the association of small vessel vasculitis like glomerulonephritis with TA. Histopathological studies showed similar features of vasculitis between the small and large vessel involvement in TA. This may explain the similar disease process that has not been well understood in TA. We believe that the persistent microscopic haematuria in the patient described is caused by TA associated glomerulonephritis. A series of investigations ruled out other causes of glomerular microscopic haematuria like autoimmune or infection related glomerulonephritis.

摘要

我们描述了一例患有大动脉炎(TA)的患者出现持续性镜下血尿的病例。已排除泌尿系统病因。传统上,TA仅累及大动脉,如主动脉及其分支。有证据表明,像肾小球肾炎这样的小血管炎与TA有关。组织病理学研究显示,TA中小血管和大血管受累的血管炎特征相似。这可能解释了TA中尚未被充分理解的相似疾病过程。我们认为,所描述患者的持续性镜下血尿是由TA相关的肾小球肾炎引起的。一系列检查排除了肾小球镜下血尿的其他原因,如自身免疫性或感染相关性肾小球肾炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ec/6716771/066d972433ca/cureus-0011-00000005024-i01.jpg

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