Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Biomaterials. 2019 Dec;223:119459. doi: 10.1016/j.biomaterials.2019.119459. Epub 2019 Aug 30.
Combination of photodynamic therapy (PDT) and photothermal therapy (PTT) generally requires different components to build a composite irradiated with different excitation lights. One component photoactive agent for enhanced combination of PDT and PTT under the excitation of a single wavelength light source is more urgent in tumor phototherapy via adjusting spatial arrangement of photoactive units. Herein, porphyrin-based covalent organic framework nanoparticles (COF-366 NPs) were synthesized to control the orderly spatial arrangement of the photoactive building units and firstly used for antitumor therapy in vivo. COF-366 NPs provide the simultaneous therapy of PDT and PTT under a single wavelength light source with the monitoring of photoacoustic (PA) imaging, which makes the operation simpler and more convenient. COF-366 NPs had achieved good phototherapy effect even in the face of large tumors. The prepared multifunctional COF-366 NPs open up a new avenue to phototherapeutic materials and expand the application range of covalent organic framework.
光动力疗法（PDT）和光热疗法（PTT）的联合通常需要不同的组件来构建用不同激发光照射的复合材料。在单一波长光源的激发下，增强 PDT 和 PTT 联合作用的一种光活性试剂更迫切需要通过调整光活性单元的空间排列来进行肿瘤光疗。本文合成了基于卟啉的共价有机骨架纳米粒子（COF-366 NPs），以控制光活性构建单元的有序空间排列，并首次将其用于体内抗肿瘤治疗。COF-366 NPs 提供了在单一波长光源下的 PDT 和 PTT 的联合治疗，并可通过光声（PA）成像进行监测，这使得操作更简单、更方便。即使面对大肿瘤，COF-366 NPs 也能实现良好的光疗效果。所制备的多功能 COF-366 NPs 为光疗材料开辟了新途径，并扩展了共价有机骨架的应用范围。
