Laboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
Laboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México; Subdirección de Enseñanza, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
Arch Med Res. 2019 May;50(4):207-213. doi: 10.1016/j.arcmed.2019.08.003. Epub 2019 Sep 26.
Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy (H MRS) at 3T, in 10 drug-naïve, first-episode psychosis (FEP) patients with those in 9 matched healthy control subjects. The results revealed a significant GSH deficit in FEP patients (0.92 ± 0.24 × 10) compared to the healthy control group (1.10 ± 0.10 × 10) (U = 25.00, p = 0.02), as well as a positive correlation between GSH levels and the Positive Symptoms subscale of the PANSS in the FEP group (ρ = 0.96; p <0.001). These preliminary findings suggest a possible role of striatal oxidative stress in early-stage psychosis that warrants further scrutiny and confirmation in larger studies.
脑谷胱甘肽（GSH）水平降低，以及相关的氧化还原失衡，被认为与精神分裂症有关，GSH 是生物组织中含量最丰富、主要的抗氧化剂。本项初步临床研究比较了 10 例未经药物治疗的首发精神病（FEP）患者和 9 例匹配的健康对照组，采用 3T 质子磁共振波谱（H MRS）检测纹状体 GSH 水平。结果显示，FEP 患者的 GSH 水平显著降低（0.92 ± 0.24×10），明显低于健康对照组（1.10 ± 0.10×10）（U = 25.00，p = 0.02），且 FEP 组的 GSH 水平与阳性症状量表（PANSS）的阳性症状分量表呈正相关（ρ = 0.96；p <0.001）。这些初步发现表明，纹状体氧化应激可能在早期精神病中起作用，值得进一步在更大规模的研究中进行探究和验证。
